CAJ | 학술논문

目的探讨血清基质金属蛋白酶-9(MMP-9)、超敏C反应蛋白(hs-CRP)水平及外周血白细胞(WBC)计数与冠心病发生、发展的关系.方法选取冠心病患者105例作为冠心病组,包括稳定性心绞痛(SAP)组27例、不稳定性心绞痛(UAP)组48例和急性心肌梗死(AMI)组30例,测定血清MMP-9、hs-CRP浓度和外周血WBC计数,健康体检者40名为对照组.结果①冠心病各组MMP-9、hs-CRP、WBC较对照组显著增高(P<0.01);②AMI组血清MMP-9、hs-CRP浓度和外周血WBC计数高于其余三组(P<0.05);③UAP组血清MMP-9、hs-CRP浓度和外周血WBC计数高于其余二组(P<0.05);④SAP组血清hs-CRP浓度高于对照组(P<0.05),血清MMP-9和外周血WBC计数高于对照组,但差异无统计学意义(P>0.05);⑤MMP-9、hs-CRP水平及WBC计数与冠心病事件的严重程度呈正相关(r=0.836,P<0.01;r=0.672, P<0.01;r=0.619,P<0.01);⑥冠心病患者血清MMP-9浓度与hs-CRP浓度及外周血WBC计数呈正相关(r=0.559,P<0.01;r=0.553,P<0.01).结论血清MMP-9、hs-CRP与外周血WBC计数与冠心病不同类型及斑块稳定性有关.
목적탐토혈청기질금속단백매-9(MMP-9)、초민C반응단백(hs-CRP)수평급외주혈백세포(WBC)계수여관심병발생、발전적관계.방법선취관심병환자105례작위관심병조,포괄은정성심교통(SAP)조27례、불은정성심교통(UAP)조48례화급성심기경사(AMI)조30례,측정혈청MMP-9、hs-CRP농도화외주혈WBC계수,건강체검자40명위대조조.결과①관심병각조MMP-9、hs-CRP、WBC교대조조현저증고(P<0.01);②AMI조혈청MMP-9、hs-CRP농도화외주혈WBC계수고우기여삼조(P<0.05);③UAP조혈청MMP-9、hs-CRP농도화외주혈WBC계수고우기여이조(P<0.05);④SAP조혈청hs-CRP농도고우대조조(P<0.05),혈청MMP-9화외주혈WBC계수고우대조조,단차이무통계학의의(P>0.05);⑤MMP-9、hs-CRP수평급WBC계수여관심병사건적엄중정도정정상관(r=0.836,P<0.01;r=0.672, P<0.01;r=0.619,P<0.01);⑥관심병환자혈청MMP-9농도여hs-CRP농도급외주혈WBC계수정정상관(r=0.559,P<0.01;r=0.553,P<0.01).결론혈청MMP-9、hs-CRP여외주혈WBC계수여관심병불동류형급반괴은정성유관.
Objective To investigate whether levels of matrix metalloproteinase-9(MMP-9),high sensitive C-reactive protein(hs-CRP) and white blood cell(WBC) count were affected in patients with coronary heart disease(CHD).Methods The levels of MMP-9,hs-CRP and WBC were measured in 27 patients with stable angina pectoris(SAP),48 patients with unstable angina pectoris(UAP),30 patients with acute myocardial infarction(AMI) and 40 control normal subjects.Results ①The levels of MMP-9,hs-CRP and WBC in AMI,UAP,and SAP groups were significantly higher than those of the control group(P<0.01).②The levels of MMP-9,hs-CRP and WBC in AMI group were markedly higher than UAP,SAP and control groups(P<0.05).③The levels of MMP-9,hs-CRP and WBC in UAP group were significantly higher than SAP and control groups(P<0.05).④The levels of hs-CRP in SAP group were significantly higher than those in control group(P<0.05),while the levels of MMP-9 and WBC had no significant difference between them(P>0.05).⑤The levels of MMP-9,hs-CRP and WBC were positively correlated with the severity of coronary events(r=0.836,P<0.01;r=0.672,P<0.01;r=0.619,P<0.01).⑥Significant positive correlation between the levels of MMP-9 and hs-CRP and WBC all were observed in the patients with CHD(P<0.05).Conclusion The elevation of levels of MMP-9,hs-CRP and WBC were associated with initiation and progression of CHD,and they may help predict cardiovascular events.