中国医疗前沿
中國醫療前沿
중국의료전연
CHINA HEALTHCARE INNOVATION
2013年
2期
13-14
,共2页
蛋白磷酸酶2A癌性抑制因子%MDS%AML%免疫组化
蛋白燐痠酶2A癌性抑製因子%MDS%AML%免疫組化
단백린산매2A암성억제인자%MDS%AML%면역조화
CIP2A%MDS%AML%Immunohistochemistry
目的探讨CIP2A在骨髓增生异常综合症(MDS)中的表达及意义.方法采用免疫组化SP法对31例MDS患者、19例急性髓系白血病(AML)患者(包括4例由MDS转变而来)和20例对照组骨髓单个核细胞中CIP2A蛋白质水平进行检测.结果 MDS组CIP2A蛋白的表达水平高于对照组,差异有统计学意义(P <0.05).MDS高危组CIP2A蛋白的表达水平显著高于MDS低危组(P <0.05),AML组CIP2A蛋白的表达水平显著高于MDS高危组(P <0.05).结论 CIP2A在MDS骨髓单个核细胞中高表达可能与MDS的疾病发展有关.
目的探討CIP2A在骨髓增生異常綜閤癥(MDS)中的錶達及意義.方法採用免疫組化SP法對31例MDS患者、19例急性髓繫白血病(AML)患者(包括4例由MDS轉變而來)和20例對照組骨髓單箇覈細胞中CIP2A蛋白質水平進行檢測.結果 MDS組CIP2A蛋白的錶達水平高于對照組,差異有統計學意義(P <0.05).MDS高危組CIP2A蛋白的錶達水平顯著高于MDS低危組(P <0.05),AML組CIP2A蛋白的錶達水平顯著高于MDS高危組(P <0.05).結論 CIP2A在MDS骨髓單箇覈細胞中高錶達可能與MDS的疾病髮展有關.
목적탐토CIP2A재골수증생이상종합증(MDS)중적표체급의의.방법채용면역조화SP법대31례MDS환자、19례급성수계백혈병(AML)환자(포괄4례유MDS전변이래)화20례대조조골수단개핵세포중CIP2A단백질수평진행검측.결과 MDS조CIP2A단백적표체수평고우대조조,차이유통계학의의(P <0.05).MDS고위조CIP2A단백적표체수평현저고우MDS저위조(P <0.05),AML조CIP2A단백적표체수평현저고우MDS고위조(P <0.05).결론 CIP2A재MDS골수단개핵세포중고표체가능여MDS적질병발전유관.
Objective To investigate the expression and significance of cancerous inhibitor of protein phosphatase 2A(CIP2A) in myelodysplastic syndromes(MDS). Methods The immunohistochemical SP staining was used to detect expression of CIP2A in control group and in MDS. Result Expression of CIP2A in MDS was significantly higher than that in control group(P <0.05), expression of CIP2A in control group and low-risk group had no significant difference(P >0.05). CIP2A in high-risk group was significantly higher than that in low-risk group(P <0.05). CIP2A in AML group was significantly higher than that in high-risk group(P <0.05). Conclusion The expression of CIP2A is significantly increased in MDS bone marrow mononuclear cells, and the positive expression of CIP2A is associated with the genesis and prognosis of MDS.
