中国医疗前沿
中國醫療前沿
중국의료전연
CHINA HEALTHCARE INNOVATION
2013年
4期
18-19
,共2页
原发性肝癌%肝肠钙粘连蛋白%淋巴结转移%门静脉癌栓
原髮性肝癌%肝腸鈣粘連蛋白%淋巴結轉移%門靜脈癌栓
원발성간암%간장개점련단백%림파결전이%문정맥암전
Primary hepatoma%Liver-intestine cadherin%lymph node metastasis%Tumor thrombi in portal vein
目的探讨肝肠钙粘连蛋白(LI-cadherin)在肝细胞肝癌中的表达水平及其临床意义.方法应用免疫组织化学链霉素亲生物素-过氧化酶标记法(S-P)检测LI-cadherin蛋白在62例肝癌组织、30例癌旁肝组织中的表达水平,并分析其与临床病理学特征之间的关系.结果肝癌组织中LI-cadherin蛋白阳性表达率为64.5%(40/62),在癌旁组织中其阳性表达率为26.7%(8/30),LI-cadherin蛋白的过表达与肝癌细胞的分化程度、癌栓的形成及淋巴结转移等临床病理因素有关(P <0.05).结论 LI-cadherin在肝癌细胞的发生、发展过程中起重要作用.LI-cadherin蛋白的过表达与肝癌细胞的门静脉癌栓、淋巴结转移有关,提示其在肝癌的增殖、侵袭和迁移中发挥重要的作用.
目的探討肝腸鈣粘連蛋白(LI-cadherin)在肝細胞肝癌中的錶達水平及其臨床意義.方法應用免疫組織化學鏈黴素親生物素-過氧化酶標記法(S-P)檢測LI-cadherin蛋白在62例肝癌組織、30例癌徬肝組織中的錶達水平,併分析其與臨床病理學特徵之間的關繫.結果肝癌組織中LI-cadherin蛋白暘性錶達率為64.5%(40/62),在癌徬組織中其暘性錶達率為26.7%(8/30),LI-cadherin蛋白的過錶達與肝癌細胞的分化程度、癌栓的形成及淋巴結轉移等臨床病理因素有關(P <0.05).結論 LI-cadherin在肝癌細胞的髮生、髮展過程中起重要作用.LI-cadherin蛋白的過錶達與肝癌細胞的門靜脈癌栓、淋巴結轉移有關,提示其在肝癌的增殖、侵襲和遷移中髮揮重要的作用.
목적탐토간장개점련단백(LI-cadherin)재간세포간암중적표체수평급기림상의의.방법응용면역조직화학련매소친생물소-과양화매표기법(S-P)검측LI-cadherin단백재62례간암조직、30례암방간조직중적표체수평,병분석기여림상병이학특정지간적관계.결과간암조직중LI-cadherin단백양성표체솔위64.5%(40/62),재암방조직중기양성표체솔위26.7%(8/30),LI-cadherin단백적과표체여간암세포적분화정도、암전적형성급림파결전이등림상병리인소유관(P <0.05).결론 LI-cadherin재간암세포적발생、발전과정중기중요작용.LI-cadherin단백적과표체여간암세포적문정맥암전、림파결전이유관,제시기재간암적증식、침습화천이중발휘중요적작용.
Objective To explore the expression level and clinical significance of LI(liver-intestine)-cadherin in hepatocellular carcinoma. Methods Immunohistochemical staining S-P(streptavidin-peroxidase) method was used to detect the expression of the LI-cadherin in 62 cases of hepatocellular carcinoma, 32 cases of corresponding paracancerous tissues. The relationships with its clinicopathological characteristics were analyzed. Results The positive rates of LI-cadherin protein were 64.5% (40/62) in hepatocellular carcinoma tissues, 26.7% (8/30) in paracancerous tissues. Conclusion The expression of LI-cadherin is up-regulated significantly in HCC. The over-expression of LI-cadherin protein is correlated with the lymph node metastasis and tumor thrombi in portal vein. It indicates that LI-cadherin may play an important role in the hyperplasia ,progression and metastasis of HCC.
