CAJ | 학술논문

1例7岁女性儿童,确诊急性淋巴细胞白血病3年,既往无药物和食物过敏史.治疗期间在第一次使用注射用两性霉素B脂质体30 min后,出现呼吸困难、寒战、体温39℃,无头痛、低血压.立即停止输注注射用两性霉素B脂质体,给予盐酸异丙嗪注射液10 mg肌肉注射、注射用赖氨匹林0.45 g入莫菲氏管,30 min后症状缓解,4 h后体温降至正常,5 h后继续使用该药物,未再发生类似反应.
1례7세녀성인동,학진급성림파세포백혈병3년,기왕무약물화식물과민사.치료기간재제일차사용주사용량성매소B지질체30 min후,출현호흡곤난、한전、체온39℃,무두통、저혈압.립즉정지수주주사용량성매소B지질체,급여염산이병진주사액10 mg기육주사、주사용뢰안필림0.45 g입막비씨관,30 min후증상완해,4 h후체온강지정상,5 h후계속사용해약물,미재발생유사반응.
One 7-year-old female patient without drug and food allergy history was diagnosed with acute lymphoblastic leukemia three years ago. Thirty minutes after the first use of amphotericin B liposome for injection, she developed dyspnea, shivering and hyperpyrexia (with the temperature of 39 ℃), while no headache and low blood pressure were found. Amphotericin B liposome for injection was withdrawn immediately. She received the intramuscular injection of promethazine hydrochloride injection 10 mg and intravenous injection of lysine-aspirin 0.45 g. After 30 minutes, her symptoms had relief, 4 hours later, the temperature dropped to normal. While this drug was used again after 5 hours, no similar reaction happened.