中国药物应用与监测
中國藥物應用與鑑測
중국약물응용여감측
CHINESE JOURNAL OF DRUG APPLICATION AND MONITORING
2013年
1期
61-62
,共2页
何首乌%药物性肝炎%肝损害%药品不良反应
何首烏%藥物性肝炎%肝損害%藥品不良反應
하수오%약물성간염%간손해%약품불량반응
Polygonum multiflorum%Drug-induced hepatitis%Liver impairment%Adverse drug reaction
病例1:患者,女,52岁,为增强免疫力自服制首乌、核桃、黑芝麻混合物(制首乌250 g、黑芝麻200 g、核桃150 g),每次15 g qd,服用约20 d后全身皮肤、巩膜黄染加重,小便颜色进行性加深,全身乏力、恶心、食欲减退,肝功能示TBIL 116μmol·L-1、ALT 1105 U·L-1、AST 1110 U·L-1,诊断为药物性肝炎.即刻停药,予保肝、利胆、降酶治疗,24 d后,患者肝功能恢复正常.病例2:患者,女,61岁,因血脂偏高而自服山楂、荷叶、生首乌混合物(每次量为各5 g泡水饮用),间断共服用生首乌约500 g,6个月后,患者眼黄,小便颜色加深,呈浓茶色,伴低热、乏力、纳差、腹胀,于外院查肝肾功能示TBIL 123.0μmol·L-1、DBIL 105.0μmol·L-1、AKP 284.0 U·L-1、γ-GT 330 U·L-1,诊断为药物性肝炎.即刻停药,予保肝、退黄、降酶等对症治疗,40 d后,患者肝功能恢复正常.
病例1:患者,女,52歲,為增彊免疫力自服製首烏、覈桃、黑芝痳混閤物(製首烏250 g、黑芝痳200 g、覈桃150 g),每次15 g qd,服用約20 d後全身皮膚、鞏膜黃染加重,小便顏色進行性加深,全身乏力、噁心、食欲減退,肝功能示TBIL 116μmol·L-1、ALT 1105 U·L-1、AST 1110 U·L-1,診斷為藥物性肝炎.即刻停藥,予保肝、利膽、降酶治療,24 d後,患者肝功能恢複正常.病例2:患者,女,61歲,因血脂偏高而自服山楂、荷葉、生首烏混閤物(每次量為各5 g泡水飲用),間斷共服用生首烏約500 g,6箇月後,患者眼黃,小便顏色加深,呈濃茶色,伴低熱、乏力、納差、腹脹,于外院查肝腎功能示TBIL 123.0μmol·L-1、DBIL 105.0μmol·L-1、AKP 284.0 U·L-1、γ-GT 330 U·L-1,診斷為藥物性肝炎.即刻停藥,予保肝、退黃、降酶等對癥治療,40 d後,患者肝功能恢複正常.
병례1:환자,녀,52세,위증강면역력자복제수오、핵도、흑지마혼합물(제수오250 g、흑지마200 g、핵도150 g),매차15 g qd,복용약20 d후전신피부、공막황염가중,소편안색진행성가심,전신핍력、악심、식욕감퇴,간공능시TBIL 116μmol·L-1、ALT 1105 U·L-1、AST 1110 U·L-1,진단위약물성간염.즉각정약,여보간、리담、강매치료,24 d후,환자간공능회복정상.병례2:환자,녀,61세,인혈지편고이자복산사、하협、생수오혼합물(매차량위각5 g포수음용),간단공복용생수오약500 g,6개월후,환자안황,소편안색가심,정농다색,반저열、핍력、납차、복창,우외원사간신공능시TBIL 123.0μmol·L-1、DBIL 105.0μmol·L-1、AKP 284.0 U·L-1、γ-GT 330 U·L-1,진단위약물성간염.즉각정약,여보간、퇴황、강매등대증치료,40 d후,환자간공능회복정상.
Case one, one 52-year-old female patient took the mixture of Polygonum multiflori radix praeparata, walnut and sesame (including Polygonum multiflori radix praeparata 250 g, walnut 200 g and sesame 150 g, 15 g once a day) for immune enhancement. About twenty days later,the patient developed yellow skin and scleral icterus, lack of power, nausea and anorexia. Results of liver function examination were as follows:TBIL 116 μmol·L-1, ALT 1105 U·L-1, AST 1110 U·L-1. The patient was hospitalized and the labortory test results met the diagnosis criteria for drug-induced hepatitis.After 24-day treatment with tiopronin, compound glycyrrhizin, silymarin and anethol trithione for liver impairment, her hepatic function returned to normal. Case two, one 61-year-old female patient took the mixture of hawthorn, lotus leaf and Polygonum multiflori radix for the treatment of hyperlipemia. After about six months, the patient developed fever, malaise, anorexia and abdominal distention. Results of liver function examination were as follows:TBIL123.0 μmol·L-1, DBIL 105.0 μmol·L-1, AKP 284.0 U·L-1, γ-GT 330 U·L-1. The patient was hospitalized and the labortory test results met the diagnosis criteria for drug-induced hepatitis. After 40-day treatment with tiopronin, compound glycyrrhizin and tanreqing injection for liver impairment, her hepatic function returned to normal.
