CAJ | 학술논문

目的:评价后程调强适形放射治疗颈及胸上段食管癌的价值.方法:2005年1月-2010年8月,笔者所在医院行后程调强适形放疗治疗33例颈段及胸上段食管癌患者.前程采用常规放疗,T 型野 DT 30 Gy/15次后,食管病灶改为后程调强适形放疗,至总量56~70 Gy,中位剂量62 Gy,双锁骨上区预防照射剂量50 Gy.结果:全组 CR 12例(36.3%)、PR 20例(60.6%).1、2年局控率为83.2%、71.6%,1、2年生存率为69.7%、62.4%,中位生存期22个月.结论:颈段及胸上段食管癌后程调强适形放疗疗效较好,治疗失败的主要原因为局部复发.
목적:평개후정조강괄형방사치료경급흉상단식관암적개치.방법:2005년1월-2010년8월,필자소재의원행후정조강괄형방료치료33례경단급흉상단식관암환자.전정채용상규방료,T 형야 DT 30 Gy/15차후,식관병조개위후정조강괄형방료,지총량56~70 Gy,중위제량62 Gy,쌍쇄골상구예방조사제량50 Gy.결과:전조 CR 12례(36.3%)、PR 20례(60.6%).1、2년국공솔위83.2%、71.6%,1、2년생존솔위69.7%、62.4%,중위생존기22개월.결론:경단급흉상단식관암후정조강괄형방료료효교호,치료실패적주요원인위국부복발.
Objective:To evaluate the therapeutic effect of late-course intensity modulated radiotherapy in patients with cervical and upper thoracic esophageal carcinoma.Method:From January 2005 to August 2010,33 cases of cervical and upper thoracic esophageal carcinoma were treated with late-course intensity modulated radiotherapy.All patients underwent conventional radiotherapy of 30 Gy in 15 fractions with“T”shape radiation fields followed by late-course intensity modulated radiotherapy,with total dose of 56~70 Gy(median 62 Gy).All patients received prophylactic irradiation of 50 Gy to the bilateral supraclavicular regions.Result:Complete response(CR)rate and partial response(PR)rate were 36.3%(12/33)and 60.6%(20/33), respectively.The 1-year and 2-year local control rate were 83.2% and 71.6%,respectively.The 1-year and 2-year overall survival rate were 69.7% and 62.4%,respectively. The median overall survival was 22 months.Conclusion:Late-course intensity modulated radiotherapy appears to be a effective treatment for cervical and upper thoracic esophageal carcinoma,but local recurrence is still the main reason of treatment failure.