中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2012年
36期
7-8
,共2页
2 型糖尿病%甲状腺结节%肥胖%胰岛素抵抗
2 型糖尿病%甲狀腺結節%肥胖%胰島素牴抗
2 형당뇨병%갑상선결절%비반%이도소저항
Metabolic syndrome%Thyroid nodule%Obesity%Insulin resistance
目的:探讨2型糖尿病(T2DM)与甲状腺结节之间的相关性.方法:以528例住院 T2DM 患者为研究对象,回顾分析其体质指数(BMI)、空腹血糖(FPG)、空腹胰岛素(FINS)、糖化血红蛋白(HbA1c)、HOMA-IR 以及甲状腺彩超检查的结果,并按肥胖、糖尿病病程、性别、年龄、血糖控制水平分析各亚组的甲状腺结节的发生情况,同时进行多因素 Logistic 回归分析.结果:T2DM 患者总甲状腺结节的患病率为64.39%,单结节、多结节分别为35.00%、65.00%,女(74.62%)多于男(57.87%)(P<0.05).甲状腺结节患病率不随病程增加而增加(P>0.05),但随年龄增加而增加,老年组(74.60%)明显高于非老年组(53.29%)(P<0.05),肥胖亚组(68.10%)高于非肥胖亚组(61.49%),但尚无统计学意义(P>0.05).HbA1C ≥7.0%亚组患病率(65.25%)较 HbA1C<7.0%亚组(61.72%)亦无明显增加(P>0.05).Logistic 多因素回归分析显示,甲状腺结节的发生与年龄、BMI、FPG、HOMA-IR 独立相关(β=1.32,OR=3.46;β=0.58, OR=2.37;β=0.61,OR=2.45;β=0.34,OR=1.87;P<0.05).结论:T2DM 患者的甲状腺结节患病率较高,年龄、体质指数、空腹血糖和胰岛素抵抗可能是 T2DM 患者甲状腺结节发生的独立预测因素.临床实践中,甲状腺结节筛查应作为2型糖尿病患者的常规检查,尤其对于肥胖的老年2型糖尿病患者.
目的:探討2型糖尿病(T2DM)與甲狀腺結節之間的相關性.方法:以528例住院 T2DM 患者為研究對象,迴顧分析其體質指數(BMI)、空腹血糖(FPG)、空腹胰島素(FINS)、糖化血紅蛋白(HbA1c)、HOMA-IR 以及甲狀腺綵超檢查的結果,併按肥胖、糖尿病病程、性彆、年齡、血糖控製水平分析各亞組的甲狀腺結節的髮生情況,同時進行多因素 Logistic 迴歸分析.結果:T2DM 患者總甲狀腺結節的患病率為64.39%,單結節、多結節分彆為35.00%、65.00%,女(74.62%)多于男(57.87%)(P<0.05).甲狀腺結節患病率不隨病程增加而增加(P>0.05),但隨年齡增加而增加,老年組(74.60%)明顯高于非老年組(53.29%)(P<0.05),肥胖亞組(68.10%)高于非肥胖亞組(61.49%),但尚無統計學意義(P>0.05).HbA1C ≥7.0%亞組患病率(65.25%)較 HbA1C<7.0%亞組(61.72%)亦無明顯增加(P>0.05).Logistic 多因素迴歸分析顯示,甲狀腺結節的髮生與年齡、BMI、FPG、HOMA-IR 獨立相關(β=1.32,OR=3.46;β=0.58, OR=2.37;β=0.61,OR=2.45;β=0.34,OR=1.87;P<0.05).結論:T2DM 患者的甲狀腺結節患病率較高,年齡、體質指數、空腹血糖和胰島素牴抗可能是 T2DM 患者甲狀腺結節髮生的獨立預測因素.臨床實踐中,甲狀腺結節篩查應作為2型糖尿病患者的常規檢查,尤其對于肥胖的老年2型糖尿病患者.
목적:탐토2형당뇨병(T2DM)여갑상선결절지간적상관성.방법:이528례주원 T2DM 환자위연구대상,회고분석기체질지수(BMI)、공복혈당(FPG)、공복이도소(FINS)、당화혈홍단백(HbA1c)、HOMA-IR 이급갑상선채초검사적결과,병안비반、당뇨병병정、성별、년령、혈당공제수평분석각아조적갑상선결절적발생정황,동시진행다인소 Logistic 회귀분석.결과:T2DM 환자총갑상선결절적환병솔위64.39%,단결절、다결절분별위35.00%、65.00%,녀(74.62%)다우남(57.87%)(P<0.05).갑상선결절환병솔불수병정증가이증가(P>0.05),단수년령증가이증가,노년조(74.60%)명현고우비노년조(53.29%)(P<0.05),비반아조(68.10%)고우비비반아조(61.49%),단상무통계학의의(P>0.05).HbA1C ≥7.0%아조환병솔(65.25%)교 HbA1C<7.0%아조(61.72%)역무명현증가(P>0.05).Logistic 다인소회귀분석현시,갑상선결절적발생여년령、BMI、FPG、HOMA-IR 독립상관(β=1.32,OR=3.46;β=0.58, OR=2.37;β=0.61,OR=2.45;β=0.34,OR=1.87;P<0.05).결론:T2DM 환자적갑상선결절환병솔교고,년령、체질지수、공복혈당화이도소저항가능시 T2DM 환자갑상선결절발생적독립예측인소.림상실천중,갑상선결절사사응작위2형당뇨병환자적상규검사,우기대우비반적노년2형당뇨병환자.
Objective: To explore the correlation between type 2 diabetes mellitus(T2DM)and thyroid nodules. Method: The data for 528 diabetic patients were retrospective studied based on different subgroups according to BMI(BMI ≥ 25 kg/m2 or less),diabetic duration,sex,age, HbA1c(≥ 7.0% or less),which included height,weight,body mass index(BMI),fasting plasma glucose(FPG),fasting insulin(FINS),diabetic history,glycosylated hemoglobin(HbA1c),insulin resistance(IR)index on homeostasis model assessment(HOMA-IR)and the ultrasonic results of thyroid glands. Thyroid nodule prevalence was recorded and Logistic regressive analysis was applied to assess whether the occurrence of thyroid nodules was correlate with the above age,BMI,FPG,HbA1c,and HOMA-IR. Result: The total prevalence of thyroid nodules was 64.39%,solitary nodule and multi nodules accounted for 35.00% and 65.00% respectively. There was higher prevalence in female T2DM(74.62%)than that in male subjects(57.87%) (P<0.05). Further analysis found that thyroid nodule prevalence was significantly elevated in aged subgroup,while slightly increased in obesity and HbA1C ≥ 7.0% subgroup. The relationship between the nodule prevalence and diabetic duration was not found. Multifactor logistic analysis showed that the occurrence of thyroid nodules independently correlated with age,BMI,FPG,HOMA-IR(β=1.32,OR=3.46,β=0.58,OR=2.37,β=0.34, OR=1.87,all P<0.05). Conclusion: There is higher thyroid nodule prevalence in T2DM,and the age,BMI,FPG and IR may be independent predictors of thyroid nodule. Thyroid nodule screening should be a routine examination in practice especially for the aged and obese T2DM population.
