CAJ | 학술논문

目的:观察氟达拉滨单药(F 方案)或联合环磷酰胺(FC 方案)治疗慢性淋巴细胞白血病的疗效及不良反应观察.方法:2006-2012年33例慢性淋巴细胞白血病患者分为3组,F 组11例,FC 组11例,CHOP 组11例,研究含氟达拉滨的治疗方案与传统 CHOP方案对慢性淋巴细胞白血病的疗效及不良反应,同时研究 F 方案与 FC 方案在治疗慢性淋巴细胞白血病方面的疗效及不良反应.结果:F 和FC 方案与 CHOP 方案相比,完全缓解率(CR)提高,总有效率(OR)提高,差异具有统计学意义(P<0.05).三种方案不良反应在血液学改变方面及在非血液学方面,差异无统计学意义(P>0.05).结论:含有氟达拉滨的方案治疗慢性淋巴细胞白血病疗效优于传统的 CHOP 一线治疗方案,氟达拉滨与环磷酰胺联合优于氟达拉滨单药治疗,不良反应无明显增加.
목적:관찰불체랍빈단약(F 방안)혹연합배린선알(FC 방안)치료만성림파세포백혈병적료효급불량반응관찰.방법:2006-2012년33례만성림파세포백혈병환자분위3조,F 조11례,FC 조11례,CHOP 조11례,연구함불체랍빈적치료방안여전통 CHOP방안대만성림파세포백혈병적료효급불량반응,동시연구 F 방안여 FC 방안재치료만성림파세포백혈병방면적료효급불량반응.결과:F 화FC 방안여 CHOP 방안상비,완전완해솔(CR)제고,총유효솔(OR)제고,차이구유통계학의의(P<0.05).삼충방안불량반응재혈액학개변방면급재비혈액학방면,차이무통계학의의(P>0.05).결론:함유불체랍빈적방안치료만성림파세포백혈병료효우우전통적 CHOP 일선치료방안,불체랍빈여배린선알연합우우불체랍빈단약치료,불량반응무명현증가.
Objective:To observe the therapeutic effects and adverse reactions of fludarabine or fludarabine combined cyclophosphamide in chronic lymphocytic leukemia(CLL). Method:33 patients with CLL were divided into three treatment group,each group was given fludarabine or fludarabine combined cyclophosphamide or CHOP regimen. Compared the the rate of complete remission( CR),overall remission( OR)and adverse reactions. Result:F and FC regimen resulted in significantly were higher CR rate than that in CHOP regimen( P<0.05).The rate of complete remission ( CR)of FC regimen was higher than that of fludarabine regimen. No significant difference was found in side effects between three regimens(P>0.05). Conclusion:Fludarabine in chronic lymphocytic leukemia(CLL)has a much better therapeutic effect than CHOP regimen. FC regimen can give higher CR rate as compared with F regimen.