CAJ | 학술논문

目的:观察缺血修饰白蛋白(ischemia modified albumin,IMA)在新生儿窒息患者中的变化,探讨其对新生儿窒息合并心肌损伤的早期诊断价值.方法:对97例新生儿窒息患者(心肌损伤44例,非心肌损伤53例;轻度窒息58例,重度窒息39例)及健康对照组51例分别于出生后3 h、6 h采血,检测IMA实验ACB值(白蛋白钴结合力,ACB),同时检测肌钙蛋白Ⅰ(cTnⅠ)、肌酸激酶同工酶(CK-MB),比较各组ACB值与cTnⅠ、CK-MB的变化.结果:新生儿窒息患者中,心肌损伤组3 h、6 h的ACB值均显著低于对照组、非心肌损伤组(P<0.01),心肌损伤组6 h与3 h的ACB值比较差异无统计学意义(P>0.05);重度窒息组3 h、6 h的ACB值均显著低于轻度窒息组、对照组(P<0.01),重度窒息组6 h与3 h的ACB值比较差异无统计学意义(P>0.05).结论:在新生儿窒息合并心肌损伤的诊断中,IMA优于cTnⅠ、CK-MB,具有敏感性更高、出现时间更早的优势,IMA的检测有助于新生儿窒息合并心肌损伤的早期诊断及对窒息程度的鉴别,使患儿得到及时干预治疗,改善预后.
목적:관찰결혈수식백단백(ischemia modified albumin,IMA)재신생인질식환자중적변화,탐토기대신생인질식합병심기손상적조기진단개치.방법:대97례신생인질식환자(심기손상44례,비심기손상53례;경도질식58례,중도질식39례)급건강대조조51례분별우출생후3 h、6 h채혈,검측IMA실험ACB치(백단백고결합력,ACB),동시검측기개단백Ⅰ(cTnⅠ)、기산격매동공매(CK-MB),비교각조ACB치여cTnⅠ、CK-MB적변화.결과:신생인질식환자중,심기손상조3 h、6 h적ACB치균현저저우대조조、비심기손상조(P<0.01),심기손상조6 h여3 h적ACB치비교차이무통계학의의(P>0.05);중도질식조3 h、6 h적ACB치균현저저우경도질식조、대조조(P<0.01),중도질식조6 h여3 h적ACB치비교차이무통계학의의(P>0.05).결론:재신생인질식합병심기손상적진단중,IMA우우cTnⅠ、CK-MB,구유민감성경고、출현시간경조적우세,IMA적검측유조우신생인질식합병심기손상적조기진단급대질식정도적감별,사환인득도급시간예치료,개선예후.
@@@@Objective:To observe the changes of ischemia modified albumin(ischemia modified albumin,IMA)in neonatal suffocation patients, to discuss ischemia modified albumin to the newborn suffocation merger myocardial injury early diagnosis value. Method:97 cases of neonatal suffocation patients and healthy controls were drew blood after the birth of 3,6 h,were tested the IMA ACB value(albumin cobalt binding force,ACB),detection troponinⅠ(cTnⅠ),creatine kinase isoenzyme(CK-MB). To compare the change of two groups ACB value,cTnⅠ,CK-MB. Result:ACB value after the birth of 3,6 h of Myocardial injury group were significantly lower than those of the control group,the myocardial injury group(P<0.01). Myocardial injury group 6 h and 3 h ACB value had no significant difference(P>0.05). ACB value after the birth of 3,6 h in Severe suffocation group were significantly lower than that in mild choking group,the control group(P<0.01). Severe suffocation group 6 h and 3 h ACB value had no significant difference(P>0.05).Conclusion:In neonatal suffocation merger myocardial injury of diagnosis,IMA is better than that of cTn Ⅰ,CK-MB,has higher sensitivity,in earlier time. IMA testing helps sleepy baby merger myocardial injury early diagnosis and the suffocation degree of identification,receives timely intervention treatment in neonatal suffocation merger myocardial injury,improves the prognosis.