CAJ | 학술논문

目的观察国产氯吡格雷(泰嘉)在经皮急诊冠状动脉介入治疗患者中应用的疗效.方法以进口氯吡格雷(波立维)为对照组,将248例经临床诊断急性冠脉综合征急诊行PCI术患者随机分为泰嘉组和进口氯吡格雷组,其中泰嘉组124例,进口氯吡格雷组124例,两治疗组PCI术前(至少6小时)口服泰嘉300?mg或进口氯吡格雷300?mg,以后每日口服泰嘉或进口氯吡格雷75?mg/d,维持至少12个月.观察两组PCI术后不良心血管事件及药物不良反应发生率的差异.结果泰嘉和进口氯吡格雷不良心血管事件及药物不良反应发生率均无明显差异.结论泰嘉费用相对低,药物疗效与不良反应发生率与进口氯吡格雷相似,泰嘉可以作为进口氯吡格雷的替代用药,值得推广.
목적관찰국산록필격뢰(태가)재경피급진관상동맥개입치료환자중응용적료효.방법이진구록필격뢰(파립유)위대조조,장248례경림상진단급성관맥종합정급진행PCI술환자수궤분위태가조화진구록필격뢰조,기중태가조124례,진구록필격뢰조124례,량치료조PCI술전(지소6소시)구복태가300?mg혹진구록필격뢰300?mg,이후매일구복태가혹진구록필격뢰75?mg/d,유지지소12개월.관찰량조PCI술후불양심혈관사건급약물불량반응발생솔적차이.결과태가화진구록필격뢰불양심혈관사건급약물불량반응발생솔균무명현차이.결론태가비용상대저,약물료효여불량반응발생솔여진구록필격뢰상사,태가가이작위진구록필격뢰적체대용약,치득추엄.
Objective To?observe?the?curative?effect?of?domestic?clopidogrel?(Talcom)?with?PCI?for?the?patients.?Method Using?the?imported?clpidogrel?(Plavix)?as?control?group,?248?cases?who?were?clinically?diagnosed?as?ACS?with?emergency?PCI?were?randomly?divided?into?Talcom?group?and?Plavix?group?with?the?same?numbers.?Both?the?two?groups?took?Tai?Jia?or?Plavix?300mg?orally.at?least?six?hours?before?PCI.?Then?the?patients?took?Talcom?or?Plavix?75mg?orally?everyday?and?lasted?for?12?months?at?least.?Finally,?observed?the?differences?of?the?two?groups?between?the?adverse?cardiovascular?events?and?the?incidence?of?adverse?drug?reactions?after?PCI.?Result There?was?no?obvious?difference?in?adverse?cardiovascular?events?and?the?incidence?of?adverse?drug?reactions?when?using?Talcom?or?Plavix.?Conclusion Talcom?is?cheaper?and?its?curative?effect?and?the?incidence?of?adverse?reaction?are?similar?to?Plavix,?so?it?can?be?used?as?an?alternative?medicine?for?Plavix.?Talcom?is?worthy?of?promotion.