CAJ | 학술논문

目的比较农民大棚肺动物模型的多层螺旋 CT(MSCT)与病理表现.资料与方法将22只成年健康豚鼠随机分为实验组(16只)和对照组(6只).实验组鼻滴吸入热吸水链霉菌抗原制剂,分为实验1组8只(持续鼻滴14d)及实验2组8只(持续鼻滴90d);对照组鼻滴吸入生理盐水.各组按不同时间给予干预后行 MSCT 扫描和病理检查,观察各组的 CT 与病理表现.结果实验组15只于2周内肺部 CT 见弥漫性磨玻璃影、大片实变影或斑片及小结节样磨玻璃影.90d 时,实验1组出现索条影,而实验2组表现为磨玻璃样斑片影、结节影及索条影混合存在.14d 内实验组病理表现有弥漫性肺泡损伤、淋巴细胞浸润性间质炎症、非干酪样肉芽肿;随后出现不同程度的肺泡间质纤维化,90d 时表现为肺泡间质纤维化、间质性肺炎;第7天时实验1组1 只豚鼠 CT 表现正常,病理表现为支气管周围炎.对照组各时间点肺野清晰,肺泡结构正常.结论农民大棚肺动物模型的影像学及病理演变与过敏性肺炎一致,病理改变早于 CT 改变.
목적비교농민대붕폐동물모형적다층라선 CT(MSCT)여병리표현.자료여방법장22지성년건강돈서수궤분위실험조(16지)화대조조(6지).실험조비적흡입열흡수련매균항원제제,분위실험1조8지(지속비적14d)급실험2조8지(지속비적90d);대조조비적흡입생리염수.각조안불동시간급여간예후행 MSCT 소묘화병리검사,관찰각조적 CT 여병리표현.결과실험조15지우2주내폐부 CT 견미만성마파리영、대편실변영혹반편급소결절양마파리영.90d 시,실험1조출현색조영,이실험2조표현위마파리양반편영、결절영급색조영혼합존재.14d 내실험조병리표현유미만성폐포손상、림파세포침윤성간질염증、비간락양육아종;수후출현불동정도적폐포간질섬유화,90d 시표현위폐포간질섬유화、간질성폐염;제7천시실험1조1 지돈서 CT 표현정상,병리표현위지기관주위염.대조조각시간점폐야청석,폐포결구정상.결론농민대붕폐동물모형적영상학급병리연변여과민성폐염일치,병리개변조우 CT 개변.
Purpose To compare the multi-slice CT (MSCT) manifestations of animal model of greenhouse farmer's lung with pathologic findings. Materials and Methods 22 adult healthy guinea pigs were divided into experimental group (16 pigs, receiving Streptomyces Thermohydroscopicus by nasal instillation) and control group (6 pigs, receiving normal sodium by nasal instillation). The experimental group was further divided into subgroup 1 (8 pigs, 14 days for nasal instillation) and subgroup 2 (8 pigs, 90 days for nasal instillation). After intervention, the pigs underwent MSCT scan and pathology examination at different times, the CT and pathologic features were observed. Results 15 pigs in the experimental group demonstrated pulmonary abnormalities within two weeks including diffuse ground glass opacities, multiple air space consolidations or patchy ground glass opacities and nodules. At 90 days, fibrous stripes were found in subgroup 1. In subgroup 2, there were combination of patchy ground glass opacities, nodules and fibrous stripes. The pathologic findings in experimental group including diffuse alveolar damage, bronchiolecentric interstitial pneumonitis with a predominance of lymphocytes or noncaseating granulomas. Then different extent interstitial fibrosis appeared. At 90 days, the histological features presented with mixed interstitial fibrosis and interstitial pneumonia. In control group, the lungs were clear with normal alverolar structure. Conclusion The radiologic features of animal model of greenhouse farmer's lung is consistent with hypersensitivity pneumonitis, but the histologic manifestation appears earlier than that of CT.