CAJ | 학술논문

目的探讨 T2校正1H-MRS 定量分析慢性丙型肝炎患者肝脂肪含量(HFC)的可行性.资料与方法应用3.0T 1H-MRS 定量测量43例慢性丙型肝炎患者的HFC,评价 HFC 与组织学结果及代谢物指标的相关性,分析不同丙型肝炎基因型之间 HFC 的差异.结果1H-MRS 测量的丙型肝炎的 HFC 范围为1%~29%,与病理分级呈正相关(r=0.71, P<0.01);HFC 与稳态模型胰岛素抵抗指数(r=0.43, P<0.05)、稳态模型β细胞功能(r=0.42, P<0.05)、体重指数(r=0.41, P<0.05)、丙氨酸氨基转移酶(r=0.38, P<0.05)和天冬氨酸氨基转移酶(r=0.56, P<0.05)均呈正相关;HFC 与肝纤维化程度无相关性(r=-0.03, P>0.05).患者基因型包含1b 型23例,2a 型14例,混合型6例,不同丙型肝炎基因型之间 HFC 差异无统计学意义(χ2=0.37, P>0.05).结论1H-MRS 可准确定量分析慢性丙型肝炎患者的 HFC,适合临床工作.
목적탐토 T2교정1H-MRS 정량분석만성병형간염환자간지방함량(HFC)적가행성.자료여방법응용3.0T 1H-MRS 정량측량43례만성병형간염환자적HFC,평개 HFC 여조직학결과급대사물지표적상관성,분석불동병형간염기인형지간 HFC 적차이.결과1H-MRS 측량적병형간염적 HFC 범위위1%~29%,여병리분급정정상관(r=0.71, P<0.01);HFC 여은태모형이도소저항지수(r=0.43, P<0.05)、은태모형β세포공능(r=0.42, P<0.05)、체중지수(r=0.41, P<0.05)、병안산안기전이매(r=0.38, P<0.05)화천동안산안기전이매(r=0.56, P<0.05)균정정상관;HFC 여간섬유화정도무상관성(r=-0.03, P>0.05).환자기인형포함1b 형23례,2a 형14례,혼합형6례,불동병형간염기인형지간 HFC 차이무통계학의의(χ2=0.37, P>0.05).결론1H-MRS 가준학정량분석만성병형간염환자적 HFC,괄합림상공작.
Purpose To quantify hepatic fat content (HFC) using T2 corrected 1H-MR spectroscopy (1H-MRS) in patients with chronic hepatitis C (HCV). Materials and Methods Forty-three patients with chronic HCV were assessed by 1H-MRS at 3.0T. Correlations were evaluated among histological grading, metabolic indexes and HFC. The HFC differences among different HCV genotypes were also assessed. Results HFC range assessed by 1H-MRS was 1%-29%, and HFC were positively correlated with pathologic steatosis stages (r=0.71, P<0.01) . HFC was also moderately correlated with HOMA-IR (r =0.43, P<0.05), HOMA-β (r=0.42, P<0.05), BMI (r=0.41, P<0.05), ALT (r=0.38, P<0.05) and AST (r=0.56, P<0.05). HFC was not correlated with liver fibrosis (r= - 0.03, P>0.05). In 43 patients, 23 were genotype 1b, 14 were genotype 2a, and 6 were mixed type, which showed no difference in HFC measured by 1H-MRS (χ2=0.37, P>0.05). Conclusion 1H-MRS is a promising method in detecting liver steatosis in HCV patients, and it is suitable for clinical application.