CAJ | 학술논문

目的:探讨HBsAg、HBeAg定量检测与Pre-S1Ag的相关性和临床意义.方法:540例乙肝患者血清,经处理,分别进行酶联免疫吸附试验(ELISA)法检测Pre-S1Ag和时间分辨荧光定量PCR法检测HBsAg、HBeAg.对HBsAg、HBeAg(-)组别、HBeAg(+)组别以及Pre-S1Ag进行χ2检验.结果:540份血清标本定量检测显示:(1)E抗原HBeAg(+)组的HBeAg浓度为(49.77±30.78)PEIU/ml,Pre-S1Ag(+)率为81.12%;E抗原HBeAg(-)组的HBeAg浓度为(0.14±0.33)PEIU/ml,Pre-S1Ag(+)率为21.60%;乙肝表面抗原HBsAg(+)组的HBsAg浓度为(139.78±89.10)PEIU/ml,Pre-S1Ag(+)率为35.00%.HBeAg(+)组和Pre-S1Ag无统计学意义,P>0.05;HBeAg(-)组、HBsAg(+)组和Pre-S1Ag具有统计学差异,P<0.05.(2)HBeAg(+)HBsAg(+)HBcAb(+),HBsAg浓度为(212.30±46.90)PEIU/ml,Pre-S1Ag(+)率为81.12%;HBeAb(+)HBsAg(+)HBcAb(+),HBsAg浓度为(139.78±89.10)PEIU/ml,Pre-S1Ag(+)率为27.95%.结论:通过检测Pre-S1Ag可以了解乙肝患者体内是否存在病毒复制情况.
목적:탐토HBsAg、HBeAg정량검측여Pre-S1Ag적상관성화림상의의.방법:540례을간환자혈청,경처리,분별진행매련면역흡부시험(ELISA)법검측Pre-S1Ag화시간분변형광정량PCR법검측HBsAg、HBeAg.대HBsAg、HBeAg(-)조별、HBeAg(+)조별이급Pre-S1Ag진행χ2검험.결과:540빈혈청표본정량검측현시:(1)E항원HBeAg(+)조적HBeAg농도위(49.77±30.78)PEIU/ml,Pre-S1Ag(+)솔위81.12%;E항원HBeAg(-)조적HBeAg농도위(0.14±0.33)PEIU/ml,Pre-S1Ag(+)솔위21.60%;을간표면항원HBsAg(+)조적HBsAg농도위(139.78±89.10)PEIU/ml,Pre-S1Ag(+)솔위35.00%.HBeAg(+)조화Pre-S1Ag무통계학의의,P>0.05;HBeAg(-)조、HBsAg(+)조화Pre-S1Ag구유통계학차이,P<0.05.(2)HBeAg(+)HBsAg(+)HBcAb(+),HBsAg농도위(212.30±46.90)PEIU/ml,Pre-S1Ag(+)솔위81.12%;HBeAb(+)HBsAg(+)HBcAb(+),HBsAg농도위(139.78±89.10)PEIU/ml,Pre-S1Ag(+)솔위27.95%.결론:통과검측Pre-S1Ag가이료해을간환자체내시부존재병독복제정황.