CAJ | 학술논문

目的:对新一代生物降解型纳米载药聚合物宫内节育系统的构建及应用前景进行分析.方法:从宫内节育系统的发展历史以及创新发展趋势、生物可降解纳米载药缓释复合材料探索现状以及未来发展走向、高相容性纳米载药缓释宫内系统构建的可行性分析及应用前景三个方面进行阐述和分析.结果:几丁聚糖(Chitosan)/聚乳酸(PLLA)复合材料生物可降解纳米载药聚合物支架因其成本低、生物相容性高、制作简单、可降解有望取代传统金属和塑料型支架,具有极大的社会和经济效益.结论:生物可降解材料及纳米控释载药系统结合有望构建新一代节育产品运用于临床.
목적:대신일대생물강해형납미재약취합물궁내절육계통적구건급응용전경진행분석.방법:종궁내절육계통적발전역사이급창신발전추세、생물가강해납미재약완석복합재료탐색현상이급미래발전주향、고상용성납미재약완석궁내계통구건적가행성분석급응용전경삼개방면진행천술화분석.결과:궤정취당(Chitosan)/취유산(PLLA)복합재료생물가강해납미재약취합물지가인기성본저、생물상용성고、제작간단、가강해유망취대전통금속화소료형지가,구유겁대적사회화경제효익.결론:생물가강해재료급납미공석재약계통결합유망구건신일대절육산품운용우림상.
Objective:To analyze the construction and application prospects of biodegradable sustained-released nanoparticle drug-loaded intrauterine contraceptive system.Methods:Described from the developing history of intrauterine contraceptive system, current and future development of biodegradable sustained-released drug-loaded composites, feasibility analysis and application prospects of sustained-released nanoparticle drug-loaded intrauterine contraceptive system.Results:Chitosan/poly-lactic acid (PLLA) composite biodegradable nanoparticle drug-loaded polymer scaffold is expected to replace the traditional metal and plastic bracket because of its low cost, high biocompatibility, simple making, biodegradable and great social and economic benefits.Conclusion:Biodegradable sustained-released nanoparticle drug-loaded intrauterine contraceptive system is expected to be used in clinical.