CAJ | 학술논문

目的:探讨甘露聚糖肽注射液联合抗菌药物预防胆囊切除术后并发感染的临床效果.方法:胆囊切除术患者198例,随机分为试验组和对照组.对照组采用常规治疗,并按药敏试验选择对症抗生素.试验组在对照组基础上应用甘露聚糖肽注射液,术前3天~术后1周应用甘露聚糖肽注射液(10~20)mg/d.观察患者临床体征变化和免疫学指标的改变.结果:胆囊切除术患者术毕时CD3+、CD4+、CD4+/CD8+、NK细胞免疫学指标较术前明显下降,但试验组术后4天、7天较术前、术毕明显升高,较对照组也显著提升(P<0.05).试验组并发感染率为8.08%,比对照组降低了10.10%(χ2=4.43,P=0.035).试验组患者术后肛门排气时间为(23.27±3.81)h,平均住院时间为(3.30±1.87)天,与对照组比较,差异具有统计学意义(P=0.046,P=0.011).试验组术后第4天、第7天临床总有效率分别为74.75%、90.91%,明显高于对照组,但两组比较无统计学差异(P>0.05).结论:甘露聚糖肽注射液能提高患者免疫功能,增强患者身体对感染的抵抗力,降低并发感染发生率.
목적:탐토감로취당태주사액연합항균약물예방담낭절제술후병발감염적림상효과.방법:담낭절제술환자198례,수궤분위시험조화대조조.대조조채용상규치료,병안약민시험선택대증항생소.시험조재대조조기출상응용감로취당태주사액,술전3천~술후1주응용감로취당태주사액(10~20)mg/d.관찰환자림상체정변화화면역학지표적개변.결과:담낭절제술환자술필시CD3+、CD4+、CD4+/CD8+、NK세포면역학지표교술전명현하강,단시험조술후4천、7천교술전、술필명현승고,교대조조야현저제승(P<0.05).시험조병발감염솔위8.08%,비대조조강저료10.10%(χ2=4.43,P=0.035).시험조환자술후항문배기시간위(23.27±3.81)h,평균주원시간위(3.30±1.87)천,여대조조비교,차이구유통계학의의(P=0.046,P=0.011).시험조술후제4천、제7천림상총유효솔분별위74.75%、90.91%,명현고우대조조,단량조비교무통계학차이(P>0.05).결론:감로취당태주사액능제고환자면역공능,증강환자신체대감염적저항력,강저병발감염발생솔.
Objective:To observe the Clinical research of Mannatide Injection in reducing the cholecystectomy concurrent infection combination with antibiotics.Methods:198 patients with gallbladder cancer were divided into treatment group(n=99)and control group(n=99) randomly,The patients in control group were administrated with conventional therapy,according to drug sensitivity test of choice for the symptomatic antibiotic.The patients in treatment group were administrated with Mannatide Injection (10~20)mg/d from 3d before operative to to 1 weeks post-operation on the basis of the control group.The level of immunity indexes were investigated and clinical effects were observed postoperatively. Results:There were no significant differences in the content of CD3+、CD4+、CD4+/CD8+、NK between the two groups immediately after operation,all of the immunity indexes were decreased significantly.All of the immunity indexes were superior to preoperation in treatment group significantly at the forth postoperative day and the seventh postoperative day,and there were significant differences between two groups(P<0.05). The total infection of the treatment group was 8.08%,lower than in control group 10.10%(χ2=4.43,P=0.035).Al the patients of the treatment group postoperative anal exhaust time was (23.27±3.81)h,the average hospitalization time was (3.30±1.87) days,and there were significant differences between two groups(P=0.046,P=0.011).The clinical total effective rate of the treatment group was 74.75%,90.91%at the Forth postoperative day and the seventh postoperative day,significantly higher than that of control group,but there were no significant differences between two group (P>0.05). Conclusion:Mannatide injection can improve the immune function of patients,enhance the body‘s resistance to infection,reduce the infection incidence.