中国医药导刊
中國醫藥導刊
중국의약도간
CHINESE JOURNAL OF MEDICAL GUIDE
2012年
12期
2129-2130
,共2页
许稳%耿瑶%尹志良%朱献忠
許穩%耿瑤%尹誌良%硃獻忠
허은%경요%윤지량%주헌충
甘露聚糖肽注射液%开放性骨折%术后感染%免疫功能
甘露聚糖肽註射液%開放性骨摺%術後感染%免疫功能
감로취당태주사액%개방성골절%술후감염%면역공능
Mannatide Injection%Open fracture%Operation infection%Immune function
目的:探讨甘露聚糖肽注射液联合抗生素预防开放性骨折术后感染的临床效果.方法:96例开放性骨折患者随机分为试验组和对照组,各48例,对照组根据药敏试验选择对症选择抗菌药物.试验组在对照组基础上应用甘露聚糖肽注射液,术前1天开始,每天1次,10mg/次,静脉点滴,观察患者治疗前后临床症状、免疫指标的变化.结果:两组感染并发症发生率比较差异具有统计学意义(χ2=4.36,P=0.037),术后第3天创口分泌物两组比较差异具有统计学意义(χ2=3.85,P=0.049).术后第4、7天时试验组CD3+、CD4+、CD4+/CD8+和NK细胞各项指标均高于对照组,且差异具有统计学意义(P<0.05).试验组患者平均住院时间为(21.12±3.97)天,较对照组(23.89±4.05)天缩短了2.77天,两组比较差异具有统计学意义(P=0.033).但术后第4、7天临床总有效率两组比较差异无统计学意义(P>0.05).结论:甘露聚糖肽注射液可提高患者免疫功能,促进机体恢复,缩短住院时间,提高临床疗效,值得推广应用.
目的:探討甘露聚糖肽註射液聯閤抗生素預防開放性骨摺術後感染的臨床效果.方法:96例開放性骨摺患者隨機分為試驗組和對照組,各48例,對照組根據藥敏試驗選擇對癥選擇抗菌藥物.試驗組在對照組基礎上應用甘露聚糖肽註射液,術前1天開始,每天1次,10mg/次,靜脈點滴,觀察患者治療前後臨床癥狀、免疫指標的變化.結果:兩組感染併髮癥髮生率比較差異具有統計學意義(χ2=4.36,P=0.037),術後第3天創口分泌物兩組比較差異具有統計學意義(χ2=3.85,P=0.049).術後第4、7天時試驗組CD3+、CD4+、CD4+/CD8+和NK細胞各項指標均高于對照組,且差異具有統計學意義(P<0.05).試驗組患者平均住院時間為(21.12±3.97)天,較對照組(23.89±4.05)天縮短瞭2.77天,兩組比較差異具有統計學意義(P=0.033).但術後第4、7天臨床總有效率兩組比較差異無統計學意義(P>0.05).結論:甘露聚糖肽註射液可提高患者免疫功能,促進機體恢複,縮短住院時間,提高臨床療效,值得推廣應用.
목적:탐토감로취당태주사액연합항생소예방개방성골절술후감염적림상효과.방법:96례개방성골절환자수궤분위시험조화대조조,각48례,대조조근거약민시험선택대증선택항균약물.시험조재대조조기출상응용감로취당태주사액,술전1천개시,매천1차,10mg/차,정맥점적,관찰환자치료전후림상증상、면역지표적변화.결과:량조감염병발증발생솔비교차이구유통계학의의(χ2=4.36,P=0.037),술후제3천창구분비물량조비교차이구유통계학의의(χ2=3.85,P=0.049).술후제4、7천시시험조CD3+、CD4+、CD4+/CD8+화NK세포각항지표균고우대조조,차차이구유통계학의의(P<0.05).시험조환자평균주원시간위(21.12±3.97)천,교대조조(23.89±4.05)천축단료2.77천,량조비교차이구유통계학의의(P=0.033).단술후제4、7천림상총유효솔량조비교차이무통계학의의(P>0.05).결론:감로취당태주사액가제고환자면역공능,촉진궤체회복,축단주원시간,제고림상료효,치득추엄응용.
Objective:To observe the Clinical effect of Mannatide Injection combined with antimicrobial agents in preventing the open fracture postoperative infection.Methods:96 patients with open fractures were divided into treatment group(n=48)and control group(n=48) randomly,The patients in control group were administrated with conventional therapy,according to drug sensitivity test of choice for the symptomatic antibiotic.The patients in treatment group were administrated with Mannatide Injection 10mg/d from 1d before operative to to 6d post-operation on the basis of the control group.The level of immunity indexes were investigated and clinical effects were observed postoperatively. Results:There were significant differences in the two groups in terms of infection complications(χ2=4.36,P=0.037)and wound secretions 3 ds post-operation(χ2=3.85,P=0.049).There were no significant differences in the content of CD3+、CD4+、CD4+/CD8+、NK between the two groups at the forth postoperative day and the seventh postoperative day(P<0.05).The average hospitalization time of treatment group was (21.12±3.97) days,2.77 days shorter than the control group (23.89±4.05) days,there were no significant differences between the two groups. There were no significant differences between the two groups at the forth postoperative day and the seventh postoperative day (P>0.05) in terms of total clinical effective rate.Conclusion:Mannatide injection is worthy of popularization and application,which can improve the immune function of patients,promote the body recovery,Shorten hospital stays,and improve the clinical efficacy.