CAJ | 학술논문

目的:探讨阿托伐他汀联合拜阿司匹林在脑梗死再发预防方面的作用.方法:将首发脑梗死的老年患者256例随机分为研究组和对照组两组,所有患者均常规进行基础疾病的相应治疗,研究组给予拜阿司匹林联合阿托伐他汀治疗;对照组给予拜阿司匹林治疗,血脂控制方面使用非他汀类药物治疗.并分别于入院时及治疗后第3、6、12个月动态监测患者血液流变学、血脂水平等变化,并对患者颈动脉粥样斑块的积分变化行评估,以及1年内患者脑梗死的再发生率进行比较.结果:在脑梗死的再发率方面,研究组为3.8%,较对照组的10.1%明显降低(P<0.01).两组患者在血液流变学变化、血脂水平变化方面,在治疗前后比较差异具有统计学意义(P<0.05),组间比较差异无统计学意义(P>0.05).研究组患者在颈动脉斑块积分变化方面,治疗前后比较差异具有统计学意义(P>0.05),而对照组治疗前后比较差异无统计学意义(P>0.05),治疗后的两组之间比较差异具有统计学意义(P>0.05).结论:在预防脑梗死的再发生治疗方面,阿托伐他汀联合拜阿司匹林可以达到很好的治疗效果,明显优于单用拜阿司匹林治疗.
목적:탐토아탁벌타정연합배아사필림재뇌경사재발예방방면적작용.방법:장수발뇌경사적노년환자256례수궤분위연구조화대조조량조,소유환자균상규진행기출질병적상응치료,연구조급여배아사필림연합아탁벌타정치료;대조조급여배아사필림치료,혈지공제방면사용비타정류약물치료.병분별우입원시급치료후제3、6、12개월동태감측환자혈액류변학、혈지수평등변화,병대환자경동맥죽양반괴적적분변화행평고,이급1년내환자뇌경사적재발생솔진행비교.결과:재뇌경사적재발솔방면,연구조위3.8%,교대조조적10.1%명현강저(P<0.01).량조환자재혈액류변학변화、혈지수평변화방면,재치료전후비교차이구유통계학의의(P<0.05),조간비교차이무통계학의의(P>0.05).연구조환자재경동맥반괴적분변화방면,치료전후비교차이구유통계학의의(P>0.05),이대조조치료전후비교차이무통계학의의(P>0.05),치료후적량조지간비교차이구유통계학의의(P>0.05).결론:재예방뇌경사적재발생치료방면,아탁벌타정연합배아사필림가이체도흔호적치료효과,명현우우단용배아사필림치료.
Objective:To explore the clinical effect of the combination of atorvastatin and bayaspirin on prevention of the recurrence of cerebral infarction in the elderly.Methods:256 old patients aged more than 60 years with first brain infarction were randomly divided into two groups. The treatment group (n=132)received the combined treatment of atorvastatin and bayaspirin, 124 cases of the control group were given bayaspirin and other non-statin cholesterol-lowering drugs. The basic treatments of two groups were same. The changes of hemorheology values, the contents of blood lipid and the scores of carotid artery plaque were monitored dynamically at the end of3 rd,6th and12th months after treatment. And the recurrence rate of cerebral infarction within one year was calculated.Results:The recurrence rate of the cerebral infarction in treatment group(3.4%)was significantly lower than the control group(10.1%)(P<0.01). In two groups, there were significant difference between pre and post treatment in the changes of hemorheology values, the contents of blood lipid and the scores of carotid artery plaque(P<0.05), but there were no significant difference between two groups(P>0.05).In the treatment group, there was significant differences between pre and post treatment in the change of the score of carotid artery plaque(P>0.05),but there was no difference in the control groups(P>0.05), there was significant difference between two groups(P>0.05).Conclusion:The curative effect of atorvastatin combined with bayaspirin is superior to bayaspirin alone on prevention of recurrence of cerebral infarction in the elderly.