CAJ | 학술논문

目的:研究尾加压素Ⅱ(UⅡ)与老年高血压患者颈动脉粥样硬化的相关性.方法:采用放免法测定130例老年高血压患者及72例健康老年人血浆UⅡ浓度,并使用颈动脉超声测定颈动脉内中膜厚度(IMT),根据IMT程度将高血压患者分为IMT0、IMT1、IMT2三组.结合UⅡ、IMT对各组进行比较和综合分析.结果:高血压组颈动脉粥样硬化发生率、IMT以及血浆UⅡ水平均显著高于健康对照组组(P<0.05或P<0.01);高血压患者血浆UⅡ水平随着IMT增厚程度的加重而升高,高血压分组三组之间UⅡ水平组间比较有显著性差异(P<0.01).结论:血浆UⅡ水平升高与老年高血压患者动脉硬化发病密切相关.
목적:연구미가압소Ⅱ(UⅡ)여노년고혈압환자경동맥죽양경화적상관성.방법:채용방면법측정130례노년고혈압환자급72례건강노년인혈장UⅡ농도,병사용경동맥초성측정경동맥내중막후도(IMT),근거IMT정도장고혈압환자분위IMT0、IMT1、IMT2삼조.결합UⅡ、IMT대각조진행비교화종합분석.결과:고혈압조경동맥죽양경화발생솔、IMT이급혈장UⅡ수평균현저고우건강대조조조(P<0.05혹P<0.01);고혈압환자혈장UⅡ수평수착IMT증후정도적가중이승고,고혈압분조삼조지간UⅡ수평조간비교유현저성차이(P<0.01).결론:혈장UⅡ수평승고여노년고혈압환자동맥경화발병밀절상관.
Objective:To study the relationship between urotensinⅡ(UⅡ) and carotid athemsclemsis in elderly essential hypertension patients.Methods:One hundred and thirty elderly essential hypertension patients and seventy-two healthy old people were selected, the plasma concentration of UⅡwere measured with radioimmunoassay method, and B-mode uhmsound was used to measure carotid intima-media thickness(IMT).The patients were divided into three groups(IMT0、IMT1and IMT2)according to the IMT.Combination of UⅡ, IMT of the group to carry out a comprehensive analysis and comparison.Results:Carotid atherosclerosis incidence、IMT and the level of plasma UⅡin essential hypertension patients were significantly higher than the health of the elderly (P<0.05 or P<0.01) .The level of plasma UⅡ increased with the severity of IMT .comparison between three groups with essential hypertension patients had the significance difference(P<0.01). Conclusion:The level of plasma UⅡ were closely correlated with atherosclemsis and plaque genesis in elderly essential hypertension parlents.