CAJ | 학술논문

目的:分析并比较地佐辛与吗啡治疗晚期癌痛的临床疗效及副作用,为临床选择合适的镇痛药物提供理论依据.方法:将我院自2010年10月至2011年8月期间收治的晚期癌症并伴有中度及重度疼痛的62例病人根据就诊时间顺序随机分成观察组以及对照组各31例,观察组病人应用地佐辛注射液进行治疗,对照组应用吗啡注射液,观察两组的镇痛疗效、生活质量评分以及副作用.结果:观察组与对照组的总有效率分别为86.7%和92.6%,两组病人的疼痛缓解疗效无显著差异(P>0.05),不具有统计学意义;两组病人给药后的生活质量比给药前均出现显著改善(P<0.01),具有统计学意义.两组间相比,未见显著差异(P>0.05),不具有统计学意义;5例病人由于发生副作用而中途退出,其中观察组1例(3.2%),吗啡组有4例(12.9%).观察组出现恶心、呕吐、眩晕等副作用的发生率低于观察组(P<0.01),表明观察组副作用较对照组少.结论:地佐辛治疗晚期癌痛的临床疗效同吗啡基本相当,但地佐辛的副作用较轻,值得在临床上广泛推广应用.
목적:분석병비교지좌신여마배치료만기암통적림상료효급부작용,위림상선택합괄적진통약물제공이론의거.방법:장아원자2010년10월지2011년8월기간수치적만기암증병반유중도급중도동통적62례병인근거취진시간순서수궤분성관찰조이급대조조각31례,관찰조병인응용지좌신주사액진행치료,대조조응용마배주사액,관찰량조적진통료효、생활질량평분이급부작용.결과:관찰조여대조조적총유효솔분별위86.7%화92.6%,량조병인적동통완해료효무현저차이(P>0.05),불구유통계학의의;량조병인급약후적생활질량비급약전균출현현저개선(P<0.01),구유통계학의의.량조간상비,미견현저차이(P>0.05),불구유통계학의의;5례병인유우발생부작용이중도퇴출,기중관찰조1례(3.2%),마배조유4례(12.9%).관찰조출현악심、구토、현훈등부작용적발생솔저우관찰조(P<0.01),표명관찰조부작용교대조조소.결론:지좌신치료만기암통적림상료효동마배기본상당,단지좌신적부작용교경,치득재림상상엄범추엄응용.
Objective:To analyze and compare the clinical curative effect and side effect of dezocine and morphine in the treatment of advanced cancer pain,and to provide a theoretical basis for clinical choice of suitable analgesic drugs.Methods:In our hospital from 2010 October to 2011 August from advanced cancer and associated with moderate and severe pain of 62 patients according to the time sequence of seeing doctor were randomly divided into observation group and control group with 31 cases in each group, the observation group were applied dezocine injection for treatment, the control group used morphine injection, observe two groups of analgesic efficacy, quality of life score as well as the side effects.Results:In the observation group and the control group in the total efficiency were 86.7% and 92.6%, the two group of patient pain relief efficacy without significant difference (P>0.05), do not have statistical significance; the two groups of patients after administration of the quality of life than the previous administration were significantly improved (P<0.01), with statistical significance.Among the two groups, but there were no significant difference (P>0.05), no statistically significant;5 patients due to the occurrence of side effects and withdrawal, the observation group of 1 cases (3.2%), morphine group consisted of 4 patients (12.9%).The observation group with nausea, vomiting, dizziness and so on the incidence of side effects than the observation group (P<0.01), suggesting that the observed group side effect is less than in the control group. Conclusion:Dezocine in treatment of late cancer pain with morphine clinical curative effect quite basic, but dezocine side effects are relatively light, worthy of clinical application.