CAJ | 학술논문

目的:观察埃索美拉唑预防脑卒中并发胃食管反流病的疗效和安全性.方法:选择80例脑卒中患者随机均分为治疗组和对照组.治疗组选用埃索美拉唑治疗;对照组选用法莫替丁治疗,疗程均为2周.比较两组防止脑卒中并发胃食管反流病及伴随症状的情况.结果:治疗组有4例出现了胃食管反流,发生率为10.0%,对照组有11例出现了胃食管反流,发生率27.5%,差异有显著性(P<0.05).药物不良反应发生率差异无显著性(P>0.05).结论:埃索美拉唑镁肠溶片为一种预防脑卒中并发胃食管反流病安全、有效的药物.
목적:관찰애색미랍서예방뇌졸중병발위식관반류병적료효화안전성.방법:선택80례뇌졸중환자수궤균분위치료조화대조조.치료조선용애색미랍서치료;대조조선용법막체정치료,료정균위2주.비교량조방지뇌졸중병발위식관반류병급반수증상적정황.결과:치료조유4례출현료위식관반류,발생솔위10.0%,대조조유11례출현료위식관반류,발생솔27.5%,차이유현저성(P<0.05).약물불량반응발생솔차이무현저성(P>0.05).결론:애색미랍서미장용편위일충예방뇌졸중병발위식관반류병안전、유효적약물.
Objective:To observe the clinical effect and safety of Esomeprazole for Preventing Stroke Complicating Gastroesophageal reflux disease.Methods:Eighty patients were randomly enrolled in the trial therapy group and the control group with 40 cases respectively. Esomeprazole and Famotidine were respectively given for two weeks in the therapy group and the control group.The frequency of Stroke Complicating Gastroesophageal reflux disease and adverse reaction were observed.Results:The incidences of Stroke Compli-cating Gastroesophageal reflux disease were 10.0%,27.5% in two groups respectively.There was significant difference between the two groups (P< 0.05) .The incidences of adverse reaction were 5.0%,7.5% in two groups respectively.There was no significant difference(P>0.05). Conclusion:Esomeprazole is a safe and effective drug for Preventing Stroke Complicating Gastroesophageal reflux disease.