CAJ | 학술논문

目的:评估胼胝体切开术治疗顽固性癫痫的有效性及安全性.方法:选取102例顽固性癫痫患者,包括全面性强直发作(GTS)、全面性强直-阵挛发作(GTCS)及失张力发作(AS)三种典型发作类型,全部行胼胝体切开术进行治疗,术后患者继续服用常规抗癫痫药物,术后随访6个月~4年,评价患者的癫痫控制状况及是否出现手术并发症.结果:恢复效果达到良好以上者共计84例,占接受该手术患者总数的82.4%,32%行胼胝体切开术的患者出现了并发症,其中1.9%为永久性并发症,无围手术期死亡病例.结论:胼胝体切开术可以有效地减少顽固性癫痫患者的发作频率,虽然具有较大的并发症风险,但对于致痫区广泛并且不能手术切除的顽固性癫痫患者,胼胝体切开术依然是有效而且必要的.
목적:평고변지체절개술치료완고성전간적유효성급안전성.방법:선취102례완고성전간환자,포괄전면성강직발작(GTS)、전면성강직-진련발작(GTCS)급실장력발작(AS)삼충전형발작류형,전부행변지체절개술진행치료,술후환자계속복용상규항전간약물,술후수방6개월~4년,평개환자적전간공제상황급시부출현수술병발증.결과:회복효과체도량호이상자공계84례,점접수해수술환자총수적82.4%,32%행변지체절개술적환자출현료병발증,기중1.9%위영구성병발증,무위수술기사망병례.결론:변지체절개술가이유효지감소완고성전간환자적발작빈솔,수연구유교대적병발증풍험,단대우치간구엄범병차불능수술절제적완고성전간환자,변지체절개술의연시유효이차필요적.
Objective:To evaluate the efficacy and safety of corpus callosotomy (CC) in the patients with refractory seizures. Methods:All 102 patients with refractory seizures underwent a corpus callosotomy (n=31) without other forms of epilepsy surgery, and continued taking regular anti-epileptic drugs.The following up from 12 to 60 months after the surgery was carried by qualified clinicians of neurosurgery,and seizure response and procedure complications were evaluated.Results:84 patients reported a fine-above recovery after surgery,accounting for 82.4% of the total patients.The risk of complication for corpus callosotomy was 32% (1.9% permanent ) and no people died in perioperative period among patients accepted corpus callosotomy.Conclusion:The corpus callosotomy is effective in reducingg eneralized seizures frequency,but corpus callosotomy is also associated with higher risk of complications, even if these were generally transient.Generally,corpus callosotomy is still effective and necessary for intractable epilepsy patients.