CAJ | 학술논문

目的:比较研究高通量血液透析与常规血液透析的临床疗效.方法:将液透析中心接受血液透析的患者68例随机分为治疗组和对照组.两组患者均选用碳酸氢盐透析液,普通肝素抗凝,于患者透析结束前30分钟停用肝素.透析液流量为每分钟500ml,血流量为每分钟220~260ml.治疗组予以高通量血液透析治疗.对照组采用常规血液透析治疗.结果:两组透析方法对患者血清尿素、肌酐的清除效果基本相同,两组比较差异无统计学意义(P>0.05).对照组在透析后血清白蛋白浓度较透析前比较,明显降低,差异有统计学意义(P<0.05);而治疗组血清白蛋白透析前后浓度变化无统计学意义(P>0.05).两组患者β2-球蛋白(β2-MG)清除效果比较,治疗组下降明显优于对照组,差异有统计学意义(P<0.05).结论:高通量血液透析对维持性血液透析患者进行治疗,有利于大中分子毒素的清除,与常规血液透析比较,在β2-球蛋白清除方面更具优势,有望提高透析患者的生活质量.
목적:비교연구고통량혈액투석여상규혈액투석적림상료효.방법:장액투석중심접수혈액투석적환자68례수궤분위치료조화대조조.량조환자균선용탄산경염투석액,보통간소항응,우환자투석결속전30분종정용간소.투석액류량위매분종500ml,혈류량위매분종220~260ml.치료조여이고통량혈액투석치료.대조조채용상규혈액투석치료.결과:량조투석방법대환자혈청뇨소、기항적청제효과기본상동,량조비교차이무통계학의의(P>0.05).대조조재투석후혈청백단백농도교투석전비교,명현강저,차이유통계학의의(P<0.05);이치료조혈청백단백투석전후농도변화무통계학의의(P>0.05).량조환자β2-구단백(β2-MG)청제효과비교,치료조하강명현우우대조조,차이유통계학의의(P<0.05).결론:고통량혈액투석대유지성혈액투석환자진행치료,유리우대중분자독소적청제,여상규혈액투석비교,재β2-구단백청제방면경구우세,유망제고투석환자적생활질량.
Objective:To compare the clinical effect between high flux hemodialysis and routine hemodialysis.Methods:68 patients for dialysis in Hemodialysis Center were randomly divided into the treatment group and the control group.In both of the groups,bicarbonate dialysate was selected,and unfractionated heparin was used for anticoagulation which was stopped 30 min before the end of dialysis.The flow of dialysate was 500 ml per min,and the flow of blood was 220~260ml per min.The treatment group was given high flux hemodialysis while the control group was given routine hemodialysis.Results:The two methods had similar clearingeffect of urea and creatinin in patients` serum, and there was no significant difference (P>0.05).Within the control group,the serum albumin level was significantly decreased after dialysis than that before treatment (P<0.05),while within the treatment group,there was no significant difference (P>0.05). The clearingeffect of β2-microglobulin (β2-MG) in the treatment group was significantly decreased than that in the control group (P<0.05). Conclusion:High flux hemodialysis used in maintenance hemodialysis patients has an advantage in the clearance of large and medium molecular toxins.And compared to routine hemodialysis,high flux hemodialysis has more advantages in the clearance of β2-MG,which is expected to improve the quality of life of dialysis patients.