CAJ | 학술논문

目的:观察甘露聚糖肽注射液对肝癌手术患者免疫功能的影响,及预防术后并发感染的临床效果.方法:72例原发性肝癌手术治疗患者随机分为试验组和对照组,各36例.对照组采用常规治疗,试验组在对照组基础上术前3天~术后7天应用甘露聚糖肽注射液.观察治疗前后免疫学指标的变化和临床疗效.结果:试验组和对照组患者术毕时组CD3+、CD4+、CD4+/CD8+、NK细胞较术前明显下降,且两组术前、术毕比较无统计学差异(P>0.05).但术后4、7天试验组各项免疫学指标明显升高,且与同期对照组比较具有统计学意义(P<0.05).试验组术后并发感染率为11.11%,与对照组比较均具有统计学差异(P=0.042,P=0.012).试验组术后4天、7天临床总有效率分别为52.78%、75.00%,明显高于对照组(50.00%、61.11%),但两组比较无统计学意义(P=0.67,P=0.19).结论:甘露聚糖肽注射液能改善肝癌手术患者免疫功能,降低术后并发感染,提高临床疗效.
목적:관찰감로취당태주사액대간암수술환자면역공능적영향,급예방술후병발감염적림상효과.방법:72례원발성간암수술치료환자수궤분위시험조화대조조,각36례.대조조채용상규치료,시험조재대조조기출상술전3천~술후7천응용감로취당태주사액.관찰치료전후면역학지표적변화화림상료효.결과:시험조화대조조환자술필시조CD3+、CD4+、CD4+/CD8+、NK세포교술전명현하강,차량조술전、술필비교무통계학차이(P>0.05).단술후4、7천시험조각항면역학지표명현승고,차여동기대조조비교구유통계학의의(P<0.05).시험조술후병발감염솔위11.11%,여대조조비교균구유통계학차이(P=0.042,P=0.012).시험조술후4천、7천림상총유효솔분별위52.78%、75.00%,명현고우대조조(50.00%、61.11%),단량조비교무통계학의의(P=0.67,P=0.19).결론:감로취당태주사액능개선간암수술환자면역공능,강저술후병발감염,제고림상료효.
Objective:To observe the influence of mannatide injection used at operation period of patients with liver cancer on the immunity function as wel as the clinical efficacy for the prevention of postoperative infection.Methods:72 patients with primary liver cancer were divided into treatment group (n=36) and control group (n=36) randomly.The patients in control group were treated with conventional treatment,and the patients in treatment group were administrated with conventional treatment combined with mannatide injection,which was used from 3d before operative to 1 weeks after operation.Changes of immunity index and clinical efficacy were observed before operative and after operation for both groups.Results:The contents of CD3+,CD4+,CD4+/CD8+ and NK were significantly decreased after operation.There was no statistical significant difference of the immunity indexes between the two groups (P>0.05) at pre-operation and after operation.Al the immunity indexes of treatment group were increased significantly at the fourth postoperative day and the seventh postoperative day contrast with preoperation,which were higher than those in control group.The postoperative infection rate of treatment group was 11.11%,which were significantly lower than that of control group (P=0.042,P=0.012).The clinical effects of treatment group were 52.78% and 75.00% at the fourth postoperative day and the seventh postoperative day,respectively,which were higher than those of control group (50.00%,61.11%),but there were no significant differences between two groups (P=0.67,P=0.19).Conclution:Mannatide injections could improve immunological function of patients with liver cancer,reduce post-operation infection and improve the clinical efficacy.