CAJ | 학술논문

目的探讨血清胱抑素 C(CysC)用于早期诊断糖尿病肾病(DN)的临床价值.方法采用全自动生化仪、胶乳增强免疫比浊法分别测定100例糖尿病患者和60例健康人员(对照组)的血清 CysC,同时测定血清肌酐(Cr)、血尿素氮(BUN)浓度并与之比较.结果血清 CysC 浓度在2型糖尿病无肾病组与健康对照组比较差异无统计学意义(P>0.05);在糖尿病肾病患者组血清 CysC、BUN、Cr浓度明显高于健康对照组,经 t 检验,差异有统计学意义(P<0.01).糖尿病肾病患者组中血清 CysC、BUN、Cr 阳性率分别为95.7%、65.7%、75.7%,血清 CysC 阳性率与 BUN 和 Cr 比较差异有统计学意义(P<0.01).结论血清 CysC 是动态观测糖尿病肾病患者肾功能的最理想指标,对诊断糖尿病肾病早期肾损伤有重要的临床参考及应用价值.
목적탐토혈청광억소 C(CysC)용우조기진단당뇨병신병(DN)적림상개치.방법채용전자동생화의、효유증강면역비탁법분별측정100례당뇨병환자화60례건강인원(대조조)적혈청 CysC,동시측정혈청기항(Cr)、혈뇨소담(BUN)농도병여지비교.결과혈청 CysC 농도재2형당뇨병무신병조여건강대조조비교차이무통계학의의(P>0.05);재당뇨병신병환자조혈청 CysC、BUN、Cr농도명현고우건강대조조,경 t 검험,차이유통계학의의(P<0.01).당뇨병신병환자조중혈청 CysC、BUN、Cr 양성솔분별위95.7%、65.7%、75.7%,혈청 CysC 양성솔여 BUN 화 Cr 비교차이유통계학의의(P<0.01).결론혈청 CysC 시동태관측당뇨병신병환자신공능적최이상지표,대진단당뇨병신병조기신손상유중요적림상삼고급응용개치.
Objective? To investigate the serum cystatin C ( CysC ) for early diagnosis of diabetic nephropathy ( DN ) and the clinical value. Methods Using automatic biochemical analyzer, latex enhanced immunoturbidimetric assay were measured in 100 cases of diabetes mellitus patients and 60 healthy people ( control group) in the serum CysC, serum creatinine ( Cr ), blood urea nitrogen ( BUN ) concentration and comparison. Results The serum CysC concentrations in type II diabetes without nephropathy group and the healthy control group to compare difference not to have statistical significance (P>0.05);in patients with diabetic nephropathy group serum CysC, BUN, Cr concentration was significantly higher than that of healthy controls, inspection by T, the difference was statistically significant ( P<0.01 ). In patients with diabetic nephropathy group serum CysC, BUN, Cr positive rates were 95.7%, 65.7%, 75.7%, the positive rate of CysC in serum and BUN and Cr had significant difference ( P<0.01 ). Conclusion Serum CysC is a dynamic observation of renal function in patients with diabetic nephropathy is the most ideal index, in the diagnosis of early diabetic nephropathy renal injury have important clinical reference and application value.