CAJ | 학술논문

目的观察阿托伐他汀对合并高脂血症脑梗死患者血液流变学的影响.方法138例合并高脂血症脑梗死患者随机分为常规治疗组(n=69)和阿托伐他汀治疗组(n=69),阿托伐他汀治疗组除进行常规治疗外,加用阿托伐他汀10 mg/d,分别于入院时及临床治疗14 d检测患者的血脂及血液流变学指标,对两组治疗前后血脂及血液流变学指标的结果进行比较.结果阿托伐他汀治疗组治疗后总胆固醇、三酰甘油、低密度脂蛋白降低,高密度脂蛋白增高,全血黏度、血浆黏度、红细胞聚集指数、红细胞刚性指数、红细胞变形指数降低,与对照组对比差别有统计学意义(P<0.05).结论合并高脂血症脑梗死患者应用阿托伐他汀能起到降低血脂及改善血液流变学作用.
목적관찰아탁벌타정대합병고지혈증뇌경사환자혈액류변학적영향.방법138례합병고지혈증뇌경사환자수궤분위상규치료조(n=69)화아탁벌타정치료조(n=69),아탁벌타정치료조제진행상규치료외,가용아탁벌타정10 mg/d,분별우입원시급림상치료14 d검측환자적혈지급혈액류변학지표,대량조치료전후혈지급혈액류변학지표적결과진행비교.결과아탁벌타정치료조치료후총담고순、삼선감유、저밀도지단백강저,고밀도지단백증고,전혈점도、혈장점도、홍세포취집지수、홍세포강성지수、홍세포변형지수강저,여대조조대비차별유통계학의의(P<0.05).결론합병고지혈증뇌경사환자응용아탁벌타정능기도강저혈지급개선혈액류변학작용.
Objective To study the effect to hemorheology of atorvastatin on patients with cerebral infarction complicated with hyperlipidemia. Methods 138 Cerebral infarction patients with hyperlipidemia were randomly divided into Control group (n=69) and atorvastatin treatment group(n=69), each group treated by conventional treatment, atorvastatin treatment group combined with atorvastatin 10 mg/d, at the time of admission and clinical treatment of 14d detected the blood lipid and blood rheology, and compared their difference. Results In Atorvastatin treated group, the total cholesterol, triglyceride and LDL droped, HDL increased, whole blood viscosity, plasma viscosity, erythrocyte aggregation index, erythrocyte rigidity index and erythrocyte deformation index decreased, compared with the control group, the difference has statistical significance (P<0.05). Conclusion Patients with cerebral infarction complicated with hyperlipidemia using atorvastatin can play to reduce blood fat and improving blood rheology.