CAJ | 학술논문

目的观察康莱特注射液联合替吉奥治疗晚期胃癌患者的疗效、毒副反应以及对生活质量的影响.方法42例晚期胃癌患者随机分为康莱特联合替吉奥化疗组(治疗组)及单纯应用替吉奥化疗组(对照组),其中治疗组22例,对照组20例.评价两组患者近期疗效、毒性反应、生活质量.结果治疗组与对照组近期疗效分别为54.5%和30.0%(P<0.05);除药物热外,治疗组毒副反应发生率均低于对照组(P<0.05);治疗组生活质量改善率明显高于对照组(P<0.05).结论康莱特联合替吉奥治疗晚期胃癌有减毒功效,同时在一定程度上能提高肿瘤患者的生活质量,且不良反应低,值得临床推广应用.
목적관찰강래특주사액연합체길오치료만기위암환자적료효、독부반응이급대생활질량적영향.방법42례만기위암환자수궤분위강래특연합체길오화료조(치료조)급단순응용체길오화료조(대조조),기중치료조22례,대조조20례.평개량조환자근기료효、독성반응、생활질량.결과치료조여대조조근기료효분별위54.5%화30.0%(P<0.05);제약물열외,치료조독부반응발생솔균저우대조조(P<0.05);치료조생활질량개선솔명현고우대조조(P<0.05).결론강래특연합체길오치료만기위암유감독공효,동시재일정정도상능제고종류환자적생활질량,차불량반응저,치득림상추엄응용.
Objective To evaluate the efficacy, toxicity and the effect on quality of life (QOL) in advanced gastric cancer patients treated by Kanglaite injection combined with S-1. Methods Fourty-two patients with advanced Gastric cancer were randomly divided into two groups:treatment group( n=22) received Kanglaite injection and S-1, and control group( n=20) only accepted chemotherapy. The response rate、toxicity and QOL were compared in two groups. Results The response rate of treatment group was 54.5%and control group was 30. 0%(P<0.05);In addition to the drug fever, the treatment group had less toxicity than control group(P<0.05), and the QOL raised significantly (P<0.05). Conclusion Kanglaite injection combined with S-1 can reduce the toxicity ,and improve the QOL and immune function.