CAJ | 학술논문

目的?研究巨噬细胞抑制因子-1(MIC-1)与增殖细胞核抗原(PCNA)在人脑星形细胞瘤中的表达,分析其表达水平与肿瘤恶性程度及病理级别的关系.方法?采用免疫组化法,检测60例不同病理级别人脑星形细胞瘤标本及5例正常人脑组织中的MIC-1和PCNA的表达.结果?MIC-1和PCNA在正常脑组织中不表达,而在人脑星形细胞瘤中的表达程度随着肿瘤的病理级别的增高明显增高,二者表达的阳性率在正常脑组织、低级别和高级别星形细胞瘤各组间比较差异均有统计学意义(P<0.05),且二者在星形细胞瘤中的表达呈正相关(P<0.05).结论?MIC-1与PCNA在人脑星形瘤细胞中的表达呈正相关,提示MIC-1的过度表达对肿瘤细胞增殖具有促进作用, MIC-1有可能成为新的候选肿瘤标志物,为判断肿瘤恶性程度及病理级别提供有价值的理论和依据.
목적?연구거서세포억제인자-1(MIC-1)여증식세포핵항원(PCNA)재인뇌성형세포류중적표체,분석기표체수평여종류악성정도급병리급별적관계.방법?채용면역조화법,검측60례불동병리급별인뇌성형세포류표본급5례정상인뇌조직중적MIC-1화PCNA적표체.결과?MIC-1화PCNA재정상뇌조직중불표체,이재인뇌성형세포류중적표체정도수착종류적병리급별적증고명현증고,이자표체적양성솔재정상뇌조직、저급별화고급별성형세포류각조간비교차이균유통계학의의(P<0.05),차이자재성형세포류중적표체정정상관(P<0.05).결론?MIC-1여PCNA재인뇌성형류세포중적표체정정상관,제시MIC-1적과도표체대종류세포증식구유촉진작용, MIC-1유가능성위신적후선종류표지물,위판단종류악성정도급병리급별제공유개치적이론화의거.
Objective?To?investigate?the?expression?of?MIC-1?and?PCNA?in?human?brain?astrocytoma??and?its?correlation?with?Malignant?degree?and?pathologic?stage.?Methods?The?expression?of?MIC-1?and?PCNA?in?60?cases?of?the?human?brain?astrocytoma?and?5?cases?of?normal?brain?tissues?were?detected?by?immunohistochemistry.?Results?MIC-1?and?PCNA?in?normal?brain?tissue?do?not?express?but?the?expression?level?with?tumor?pathological?level?increased significantly higher in the human brain astrocytoma, its expression of Positive rate in normal brain tissue, low grade and high level astrocytoma is?compared?between?the?differences?were?statistically?significant(P<0.05)?and?expression?of?MIC-1?had?a?positive?correlation?with?the?expression?of?PCNA(P<0.05).?Conclusion?Expression?of?MIC-1?had?a?positive?correlation?with?the?expression?of?PCNA?in?human?brain?astrocytoma,?Prompt?the?excessive?expression?of?MIC-1?of?tumor?cell?proliferation?with?promoting?role.?it?may?become?the?new?candidate?tumor?markers,?For?judgment?of?malignant?degree?and?pathological?grade?provide?valuable?theory?and?basis.