CAJ | 학술논문

目的?探讨GDF-15基因-3148C/G位点多态性与山西地区汉族人群中冠心病发病风险的相关性.方法?采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)的方法对118例冠心病患者和56例健康对照者GDF-15基因-3148C/G位点进行多态性分析.结果?在冠心病组中,CC、GC两种基因型频率分别为76.27%和23.73%,在正常对照组中分别为60.71%和39.29%;两组受试者-3148C/G位点的CC、GC基因型频率分布有统计学意义(χ2=4.488,P=0.034);风险基因型为GC型,OR=2.080,95%可信区间为1.050~4.121.结论?GDF-15基因-3148C/G位点中GC基因型与山西地区汉族人群中冠心病的发病风险存在一定的相关性.
목적?탐토GDF-15기인-3148C/G위점다태성여산서지구한족인군중관심병발병풍험적상관성.방법?채용취합매련반응-한제성편단장도다태성(PCR-RFLP)적방법대118례관심병환자화56례건강대조자GDF-15기인-3148C/G위점진행다태성분석.결과?재관심병조중,CC、GC량충기인형빈솔분별위76.27%화23.73%,재정상대조조중분별위60.71%화39.29%;량조수시자-3148C/G위점적CC、GC기인형빈솔분포유통계학의의(χ2=4.488,P=0.034);풍험기인형위GC형,OR=2.080,95%가신구간위1.050~4.121.결론?GDF-15기인-3148C/G위점중GC기인형여산서지구한족인군중관심병적발병풍험존재일정적상관성.
Objective?This?study?is?to?explore?the?correlation?between?polymorphism?of?-3148C/G?site?of?GDF15?gene?and?the?risk?of?coronary?heart?disease(CHD)?in?Shanxi?Han?people.?Methods?The?polymerase?chain?reaction?(PCR?)、gene sequencing and sequence flanking were used to detect and analyze?the?polymorphism?of?-3148C/G?site?of?GDF-15?gene?for?118?cases?CHD?patients?as?experimental?group?and?56?cases?patients?as?control?group.?Results?The?genotype?frequencies?of?CC、GC?were?76.27%?and?23.73%?in?the?CHD?group?and?in?the?control?group?were?60.71%?and?39.29%?respectively.?Testers of the two groups at-3148C/G CC, GC genotype frequencies distribution have a statistics mean (χ2=4.488,P=0.034);The?risk?genotype?was?GC,?OR=2.080, 95%of confident interval is 1.050-4.121. Conclusions?We?conclude?that?there?is?a?correlation?between?the?polymorphism?of?-3148C/G?site?in?GDF15?gene?and?the?risk?of?CHD?patients?in?Shanxi?Han?people.