CAJ | 학술논문

目的阐明脑钠肽(BNP)水平与妊娠期高血压性心脏病患者发病的关系.方法检测1426例妊娠期高血压疾病(妊高病)患者和3221例正常妊娠妇女血浆脑钠肽水平,比较妊高病患者与正常妊娠妇女、妊高病无心脏病患者与并发心脏病患者血浆脑钠肽水平,分析脑钠肽水平与临床参数的关系.结果妊高病患者血浆BNP水平明显高于正常妊娠妇女(P<0.01).妊高病患者中,心脏病患者BNP水平高于无心脏病患者(P<0.05).BNP水平与妊娠高血压性心脏病患者的年龄、孕周、经产与否、胎数无关,与患者心功能分级密切相关(P<0.01).结论 BNP在妊娠高血压性心脏病的诊断与病情评估中发挥重要作用,可作为潜在的生物靶点.
목적천명뇌납태(BNP)수평여임신기고혈압성심장병환자발병적관계.방법검측1426례임신기고혈압질병(임고병)환자화3221례정상임신부녀혈장뇌납태수평,비교임고병환자여정상임신부녀、임고병무심장병환자여병발심장병환자혈장뇌납태수평,분석뇌납태수평여림상삼수적관계.결과임고병환자혈장BNP수평명현고우정상임신부녀(P<0.01).임고병환자중,심장병환자BNP수평고우무심장병환자(P<0.05).BNP수평여임신고혈압성심장병환자적년령、잉주、경산여부、태수무관,여환자심공능분급밀절상관(P<0.01).결론 BNP재임신고혈압성심장병적진단여병정평고중발휘중요작용,가작위잠재적생물파점.
Objective To clarify the relationship between BNP and pregnant hypertension induced heart disease. Methods BNP in 1426 pregnant hypertension samples and 3221 normal pregnancy was detected. BNP in patients was compared to the normal, and it in patients without heart disease was compared to those with heart disease. The correlation of BNP and clinical data was analyzed. Results BNP in patients was higher than the normal. In the patients group, BNP in those with heart disease was higher than those without. There was no relationship between BNP and age, pregnant weeks, multiparity and embryo number. But it was related to cardiac functional grading. Conclusion BNP could be a marker for it playing a role in diagnosis and condition prediction of pregnant hypertension induced heart disease.