CAJ | 학술논문

目的?研究泰山散瘀膏对小鼠活血化瘀作用及作用机制.方法取小鼠28只,随机分为实验组和对照组各14只,实验组和对照组小鼠分别腹部贴覆涂有泰山散瘀膏和凡士林的透气薄膜,连续3天后通过腹腔注射抗凝鸡血至淤血模型,利用瑞氏-吉姆萨染色法油镜下观察并计算红细胞、巨噬细胞及吞噬红细胞的巨噬细胞的数量,探讨泰山散瘀膏活血化瘀的作用机制.结果注射鸡血6h后,实验组和对照组的吞噬红细胞的巨噬细胞数分别为(178.22±40.78)和(201.12±34.56),12h后实验组和对照组的吞噬红细胞的巨噬细胞数分别为(30.29±9.99)和(48.12±12.28),两组比较差异均有统计学意义(P<0.05).结论泰山散瘀膏通过明显促进巨噬细胞活化及吞噬红细胞的功能而起到活血化瘀的作用.
목적?연구태산산어고대소서활혈화어작용급작용궤제.방법취소서28지,수궤분위실험조화대조조각14지,실험조화대조조소서분별복부첩복도유태산산어고화범사림적투기박막,련속3천후통과복강주사항응계혈지어혈모형,이용서씨-길모살염색법유경하관찰병계산홍세포、거서세포급탄서홍세포적거서세포적수량,탐토태산산어고활혈화어적작용궤제.결과주사계혈6h후,실험조화대조조적탄서홍세포적거서세포수분별위(178.22±40.78)화(201.12±34.56),12h후실험조화대조조적탄서홍세포적거서세포수분별위(30.29±9.99)화(48.12±12.28),량조비교차이균유통계학의의(P<0.05).결론태산산어고통과명현촉진거서세포활화급탄서홍세포적공능이기도활혈화어적작용.
Objective To study the effects of Taishan Sanyu Plaster on eliminating blood stasis and its mechanisms. Method To explore the mechanisms of Taishan Sanyu Plaster on eliminating blood stasis, 28 mice were divided into two groups randomly,14 mice in the treatment group received abdominal pasting of Taishan Sanyu Plaster for 3 days and 14 mice in the control group received abdominal pasting of vaseline permeable membrane for 3 days. Then the mice were made into blood stasis models by abdominal injection of anticoagulant chicken blood. After Giemsa staining, erythrocytes、macrophages and macrophages which swallow erythrocytes were observed and counted. Result The number of erythrocyte–swallowing macrophages of treatment group and control group was separately 178.22±40.78 and 201.12±34.56 six hours after the injection, while the number of the two groups was 30.29±9.99 and 48.12± 12.28 twelve hours after the injection. There was a significant difference of the data between the two groups(P<0.05 ).Conclusion Taishan Sanyu Plaster can eliminate blood stasis by promoting activation of macrophages and its erythrocyte swallowing function.