CAJ | 학술논문

目的:分析胆道系统恶性肿瘤根治术后患者临床病理特点及预后影响因素.方法:回顾性分析116例于2006年1月至2010年12月在天津医科大学附属肿瘤医院接受R0手术切除的胆道系统恶性肿瘤患者预后相关因素,进一步评估不同部位胆道系统恶性肿瘤临床病理特征及辅助化疗获益情况.结果:单因素分析表明发病时肝侵犯、组织分化程度、神经血管浸润、淋巴结转移、TNM分期和化疗与否是影响胆道系统恶性肿瘤术后患者预后因素.多因素分析表明组织分化程度和化疗与否可作为独立的预后影响因子.不同部位胆道系统恶性肿瘤化疗获益情况不尽相同.结论:组织分化程度与化疗与否为胆道系统恶性肿瘤术后患者独立预后因素.不同部位的胆道系统恶性肿瘤生物学行为不尽相同,需要分别进行研究.
목적:분석담도계통악성종류근치술후환자림상병리특점급예후영향인소.방법:회고성분석116례우2006년1월지2010년12월재천진의과대학부속종류의원접수R0수술절제적담도계통악성종류환자예후상관인소,진일보평고불동부위담도계통악성종류림상병리특정급보조화료획익정황.결과:단인소분석표명발병시간침범、조직분화정도、신경혈관침윤、림파결전이、TNM분기화화료여부시영향담도계통악성종류술후환자예후인소.다인소분석표명조직분화정도화화료여부가작위독립적예후영향인자.불동부위담도계통악성종류화료획익정황불진상동.결론:조직분화정도여화료여부위담도계통악성종류술후환자독립예후인소.불동부위적담도계통악성종류생물학행위불진상동,수요분별진행연구.
Objective: This work aimed to analyze the clinicopathological characteristics and prognostic factors of biliary tract cancer patients who had undergone surgery. Methods: The medical records of 116 patients with biliary tract cancer who had undergone radical surgery in Tianjin Cancer Hospital between January 2006 and December 2010 were retrospectively analyzed. The clinicopathological characteristics and prognostic factors were analyzed. Results: Univariate analysis revealed that the liver invasion, tumor grading, lymphatic/vascular invasion, lymph node staging, tumor–node–metastasis classification of the World Health Organization, and adjuvant chemotherapy were associated with the prognosis of these patients. Multivariate analysis revealed that the tumor grades and adjuvant chemotherapy were the independent prognosis factors. The responses to adjuvant chemotherapy also varied with the tumor location. Conclusion: Tumor grading and adjuvant chemotherapy were independent prognosis factors of biliary tract cancer patients. Their biological behaviors and responses to adjuvant chemotherapy varied with the tumor location. These behaviors and responses may need to be separately considered and analyzed for effective individualized treatment.