CAJ | 학술논문

目的:探讨低剂量99mTc-甲氧基异丁基异腈(MIBI)半定量分析在乳腺断层双时相显像诊断乳腺癌中的临床意义.方法:109例乳房肿块患者和26例正常对照者为临床研究对象,使用自制乳腺显像装置进行早期和延迟图像采集,图像行半定量分析(SQA),并与病理检查结果对照.结果:正常对照组、良性病变组、乳腺癌组的早期相 T/NT 比值分别为1.09±0.18、1.77±1.36、3.98±3.11,3组比较,差异有统计学意义(P<0.05).正常对照组的早期相与延迟相T/NT比值差异无统计学意义[(1.09±0.18)vs.(1.08±0.19),P>0.05];良性病变组下降,差异有统计学意义[(1.77±1.36)vs.(1.28±0.83),P<0.05];乳腺癌组下降不明显,差异无统计学意义[(3.98±3.11)vs.(3.04±2.46),P>0.05].半定量分析诊断乳腺癌的灵敏度为97.67%(42/43),特异性为81.82%(54/66),准确性为88.07%(96/109),阳性预测值为77.78%(42/54),阴性预测值为98.18%(54/55).结论:低剂量99mTc-MIBI乳腺断层双时相显像是诊断乳腺癌的一种行之有效的方法,对鉴别乳腺良恶性病变有很好的临床应用价值.
목적:탐토저제량99mTc-갑양기이정기이정(MIBI)반정량분석재유선단층쌍시상현상진단유선암중적림상의의.방법:109례유방종괴환자화26례정상대조자위림상연구대상,사용자제유선현상장치진행조기화연지도상채집,도상행반정량분석(SQA),병여병리검사결과대조.결과:정상대조조、량성병변조、유선암조적조기상 T/NT 비치분별위1.09±0.18、1.77±1.36、3.98±3.11,3조비교,차이유통계학의의(P<0.05).정상대조조적조기상여연지상T/NT비치차이무통계학의의[(1.09±0.18)vs.(1.08±0.19),P>0.05];량성병변조하강,차이유통계학의의[(1.77±1.36)vs.(1.28±0.83),P<0.05];유선암조하강불명현,차이무통계학의의[(3.98±3.11)vs.(3.04±2.46),P>0.05].반정량분석진단유선암적령민도위97.67%(42/43),특이성위81.82%(54/66),준학성위88.07%(96/109),양성예측치위77.78%(42/54),음성예측치위98.18%(54/55).결론:저제량99mTc-MIBI유선단층쌍시상현상시진단유선암적일충행지유효적방법,대감별유선량악성병변유흔호적림상응용개치.
Objective: This study aims to investigate the clinical significance of the semi-quantitative analysis of low-dose 99mTc-methoxy isobutyl isonitrile (MIBI) double phase tomographic imaging in breast cancer diagnosis. Methods: A total of 109 patients with breast lesions and 26 normal breasts underwent double-phase 99mTc-MIBI tomographic imaging using a self-designed imaging device. The early and the delayed tumor to non-tumor ratios (T/NT) were calculated by semi-quantitative image analysis (SQA). The results were compared with that of the pathological results. Results: The early phase T/NT ratios in the normal control, benign, and breast cancer groups were 1.09±0.18, 1.77±1.36, and 3.98±3.11, respectively. The difference was statistically significant (P<0. 05). The difference of the early and delayed phase T/NT ratios in the normal control group was not statistically significant (1.09±0. 18 vs. 1.08±0.19, >0.05). The difference in the benign group was statistically significant (1.77±1.36 vs. 1.28±0.83, P<0.05), whereas that of the breast cancer group was not statistically significant (3.98±3.11 vs. 3.04±2.46, P>0.05). The sensitivity of the semi-quantitative analysis in the diagnosis of breast cancer was 97.67%, the specificity was 81.82%, and the accuracy was 88.07%. The positive and negative values were 77.78% (42/54) and 98.18% (54/55), respectively. Conclusion: Low dose 99mTc-MIBI double-phase tomography imaging is an effective method to detect breast cancer, and has great clinical value in the differentiation of malignant and benign breast lesions.