CAJ | 학술논문

目的:观察金龙胶囊先期干预联合肝动脉栓塞介入化疗(transcatheter arterial chemoembolization,TACE)治疗原发性肝癌的临床疗效.方法:将70例原发性肝癌患者随机分为两组,单纯 TACE 组36例(对照组),TACE+金龙胶囊组34例(治疗组).对照组进行E-ADM+5-FU+DDP TACE治疗1次;治疗组在对照组的基础上,于治疗前7天始口服金龙胶囊1 g/次,3次/日,连续服用5周.观察两组治疗后肿瘤病灶大小、肝功能指标、中医证候评分、KPS评分及Th1、Th2细胞因子漂移等方面的变化情况.结果:在肿瘤病灶大小变化、肝功能评价指标数值变化、KPS 评分值、中医症状评分及 Th1、Th2细胞因子浓度变化等多方面,单纯TACE组与金龙胶囊先期干预组比较,有显著性统计学差异(P<0.05).结论:研究资料显示金龙胶囊先期干预对原发性肝癌具有抑制肿瘤、减毒增效保肝、提高生存质量、增强免疫功能等疗效,且经证实无出血及凝血功能障碍等不良反应.
목적:관찰금룡효낭선기간예연합간동맥전새개입화료(transcatheter arterial chemoembolization,TACE)치료원발성간암적림상료효.방법:장70례원발성간암환자수궤분위량조,단순 TACE 조36례(대조조),TACE+금룡효낭조34례(치료조).대조조진행E-ADM+5-FU+DDP TACE치료1차;치료조재대조조적기출상,우치료전7천시구복금룡효낭1 g/차,3차/일,련속복용5주.관찰량조치료후종류병조대소、간공능지표、중의증후평분、KPS평분급Th1、Th2세포인자표이등방면적변화정황.결과:재종류병조대소변화、간공능평개지표수치변화、KPS 평분치、중의증상평분급 Th1、Th2세포인자농도변화등다방면,단순TACE조여금룡효낭선기간예조비교,유현저성통계학차이(P<0.05).결론:연구자료현시금룡효낭선기간예대원발성간암구유억제종류、감독증효보간、제고생존질량、증강면역공능등료효,차경증실무출혈급응혈공능장애등불량반응.
Objective: The objective of this study was to observe the clinical effects of early treatment with Jin-long capsules combined with transarterial chemoembolization (TACE) in primary liver cancer. Methods: Seventy patients with primary liver cancer were randomly divided into two groups, namely, the contrast group (administered with TACE only) and the treatment group (given TACE and Jin-long capsules). The contrast group received TACE treatment with E-ADM + 5-Fu + DDP once. By contrast, the treatment group was given 1 g of Jin-long capsules initially and thrice a day before the 7-day TACE regimen began, which lasted for 5 weeks (continuously). Results: The two groups significantly differed in their tumor lesion size, liver function index, TCM symptomatic score, KPS score, and cytokine switching of Th1 and Th2 (P<0.05). Conclusions: Clinical research shows that early intervention with Jin-long capsules for primary liver cancer can improve the efficiency of anticancer therapy, minimize adverse reactions, as well as protect the liver, improve the quality of life, and enhance the immune function of patients. Jin-long capsules have no adverse reactions, such as bleeding and coagulation disorders.