CAJ | 학술논문

目的:探讨18F-FDG PET/CT显像在原发性胆囊癌诊断中的价值,并与增强CT、B超及MRI进行比较.方法:收集2006年3月至2011年12月期间38例临床疑似胆囊癌而在本院行PET/CT检查的患者,其中男26例,女12例;年龄46~82岁,中位年龄69岁.患者均行PET/CT、增强CT、B超及MRI检查.全部病例均经手术病理及临床随访证实,其中35例为原发胆囊癌,3例为胆囊炎.分别统计4种影像诊断方法的真阳性率、假阳性率、真阴性率、假阴性率及诊断正确率.结果:PET/CT、增强 CT、B 超及MRI检查的真阳性率分别为100.0%、74.3%、60.0%、71.4%;假阴性率分别为0、25.7%、40.0%、28.6%;增强CT、B超及MRI检查真阴性率分别为66.7%、33.3%、66.7%;假阳性率分别为33.3%、66.7%、33.3%.诊断正确率分别为92.1%、71.1%、60.5%、68.4%.PET/CT与增强CT、B超及MRI结果比较,P值分别为0.036、0.002、0.019,均P<0.05.结论:在原发性胆囊癌诊断中,PET/CT较其他3种传统影像诊断方法准确率高.如将PET/CT结合增强CT检查,可使诊断正确率提高2.6%.故18F-FDG PET/CT显像对原发性胆囊癌的诊断具有重要的临床应用价值.
목적:탐토18F-FDG PET/CT현상재원발성담낭암진단중적개치,병여증강CT、B초급MRI진행비교.방법:수집2006년3월지2011년12월기간38례림상의사담낭암이재본원행PET/CT검사적환자,기중남26례,녀12례;년령46~82세,중위년령69세.환자균행PET/CT、증강CT、B초급MRI검사.전부병례균경수술병리급림상수방증실,기중35례위원발담낭암,3례위담낭염.분별통계4충영상진단방법적진양성솔、가양성솔、진음성솔、가음성솔급진단정학솔.결과:PET/CT、증강 CT、B 초급MRI검사적진양성솔분별위100.0%、74.3%、60.0%、71.4%;가음성솔분별위0、25.7%、40.0%、28.6%;증강CT、B초급MRI검사진음성솔분별위66.7%、33.3%、66.7%;가양성솔분별위33.3%、66.7%、33.3%.진단정학솔분별위92.1%、71.1%、60.5%、68.4%.PET/CT여증강CT、B초급MRI결과비교,P치분별위0.036、0.002、0.019,균P<0.05.결론:재원발성담낭암진단중,PET/CT교기타3충전통영상진단방법준학솔고.여장PET/CT결합증강CT검사,가사진단정학솔제고2.6%.고18F-FDG PET/CT현상대원발성담낭암적진단구유중요적림상응용개치.
Objective: This study aimed to investigate the diagnostic value of 18F-FDG PET/CT imaging in primary gallbladder carcinoma cases and compare this diagnostic value with the advantages of enhanced CT, B ultrasound, and MRI scans. Methods: Thirty-eight patients (26 males and 12 females; aged 46 to 82 years, median age = 69 years), who were clinically suspected of gallbladder carcinoma, were examined using PET/CT, CT (both plain and contrast-enhanced) scan, B ultrasound, and MRI diagnoses from March 2006 to December 2011. All of the cases were histopathologically confirmed by biopsy (21 cases) and clinical follow-up (17cases). Among these cases, 35 were primary gallbladder carcinoma and 3 were cholecystitis. The true positive rate (TPR), false positive rate (FPR), true negative rate (TNR), false negative rate (FNR), and diagnostic accuracy rate (DAR) of the four imaging modalities were calculated. Results: All of the 35 gallbladder carcinoma cases showed an increase in 18F-FDG uptake without FNR. The following results were obtained from PET/CT, contrast-enhanced CT, B ultrasound, and MRI diagnoses, respectively (P<0.05): TPRs = 100%, 74.3%, 60.0%, and 71.4%; FNRs = 0%, 25.7%, 40.0%, and 28.6%; and DARs = 92.1%, 71.1%, 60.5%, and 68.4%. TNRs were 66.7%, 33.3%, and 66.7% in the contrast-enhanced CT, B ultrasound, and MRI diagnoses, respectively, whereas FPRs were 33.3%, 66.7%, and 33.3% in the diagnostic methods. Statistically significant diagnostic results were obtained from PET/CT, enhanced CT scan, B ultrasound, and MRI (P=0.036, 0.002, and 0.019, respectively;P<0.05. Conclusion: The 18F-FDG PET/CT scan is more efficient than the traditional imaging methods, such as contrast-enhanced CT, B ultrasound, and MRI. Thus, this technique can be a useful modality for the diagnosis of gallbladder carcinoma.