CAJ | 학술논문

原发性肝癌是全球高发病率的恶性肿瘤之一.手术切除是治疗原发性肝癌的首选手段,然而手术切除后复发率、转移率高,预后差是严重制约手术治疗远期疗效的重要因素.肝癌的转移是一个多步骤、多因素相互作用的复杂过程.近年来研究发现微转移是引起肿瘤复发和转移的根源,微转移的检测对肿瘤的准确分期、指导治疗、判断预后有重要意义,目前常用肝癌微转移灶检测标志物包括端粒酶、甲胎蛋白mRNA、MicroRNAs、上皮型钙黏素、CD44v6 mRNA和细胞角蛋白.本文从肝癌微转移灶的概念背景、标本来源、检测标志物、检测方法及相关临床意义等方面对肝癌微转移的研究进展进行综述,旨在探讨微转移灶检测在肝癌临床治疗及预后中的重要意义.
원발성간암시전구고발병솔적악성종류지일.수술절제시치료원발성간암적수선수단,연이수술절제후복발솔、전이솔고,예후차시엄중제약수술치료원기료효적중요인소.간암적전이시일개다보취、다인소상호작용적복잡과정.근년래연구발현미전이시인기종류복발화전이적근원,미전이적검측대종류적준학분기、지도치료、판단예후유중요의의,목전상용간암미전이조검측표지물포괄단립매、갑태단백mRNA、MicroRNAs、상피형개점소、CD44v6 mRNA화세포각단백.본문종간암미전이조적개념배경、표본래원、검측표지물、검측방법급상관림상의의등방면대간암미전이적연구진전진행종술,지재탐토미전이조검측재간암림상치료급예후중적중요의의.
Primary liver cancer (PLC) is a malignant tumor with a very high incidence worldwide. Surgery is commonly the treatment of choice for PLC. However, tumor recurrence and metastasis after surgery seriously hamper the long-term efficacy of surgical treatment. The metastasis of hepatocellular carcinoma has long been known to involve a multi-step treatment process. Recent studies have shown that micrometastasis is the cause of tumor recurrence and metastasis. The detection of micrometastasis facilitates the accurate staging of the tumor, treatment, and prognosis. At this writing, markers for detecting liver cancer micrometastasis are available, including telomerase, al pha-fetoprotein mRNA, micro RNAs, E-cadherin, CD44v6mRNA, and cytokeratin. In this study, the researchers reviewed the research progress on the micrometastasis of liver cancer by examining the concept, source of specimen, detection methods, and clinical pathology to investigate the significance of each in the treatment and prognosis of the cancer.