中国肿瘤临床
中國腫瘤臨床
중국종류림상
CHINESE JOURNAL OF CLINICAL ONCOLOGY
2013年
4期
198-201
,共4页
张超%范宇%李伟东%李崖青%李帅%钱晓龙%林阳%刘芳芳%郎荣刚%谷峰%付丽
張超%範宇%李偉東%李崖青%李帥%錢曉龍%林暘%劉芳芳%郎榮剛%穀峰%付麗
장초%범우%리위동%리애청%리수%전효룡%림양%류방방%랑영강%곡봉%부려
乳腺浸润性微乳头状癌%L1细胞粘附分子%淋巴结转移
乳腺浸潤性微乳頭狀癌%L1細胞粘附分子%淋巴結轉移
유선침윤성미유두상암%L1세포점부분자%림파결전이
invasive micropapillary carcinoma of the breast%L1 cell adhesion molecules%lymph node metastasis
目的:探讨 L1细胞黏附分子(L1 cell adhesion molecules,L1-CAM)在乳腺浸润性微乳头状癌(Invasive micropapillary carcinoma,IMPC)中的表达及其临床意义.方法:应用免疫组织化学SP法,检测97例乳腺IMPC中L1-CAM表达,并以95例浸润性导管癌非特殊型(invasive ductal carcinoma,not otherwise specified,IDC-NOS)作为对照组.分析L1-CAM在IMPC的表达及与临床病理学特征和预后的关系.结果:L1-CAM表达于肿瘤细胞膜及间质中的脉管内皮细胞,在IMPC组主要表达于肿瘤细胞集团内细胞间的相互连接面.L1-CAM在IMPC中的表达率(50.5%)显著高于IDC-NOS组(18.9%),并与IMPC的组织学分级、脉管侵犯、淋巴结转移、间质内脉管的L1-CAM表达及肿瘤细胞的P53表达呈正相关(P<0.05),与ER、PR表达呈负相关(P<0.05).单因素分析结果显示,IMPC患者中L1-CAM表达阳性患者预后不良.多因素分析结果显示IMPC中L1-CAM表达是影响患者术后生存的独立预后因素.结论:L1-CAM可能在IMPC集团性生长、侵袭、转移中发挥重要作用,可作为IMPC预后预测的标志物及靶向治疗研究的新靶点.
目的:探討 L1細胞黏附分子(L1 cell adhesion molecules,L1-CAM)在乳腺浸潤性微乳頭狀癌(Invasive micropapillary carcinoma,IMPC)中的錶達及其臨床意義.方法:應用免疫組織化學SP法,檢測97例乳腺IMPC中L1-CAM錶達,併以95例浸潤性導管癌非特殊型(invasive ductal carcinoma,not otherwise specified,IDC-NOS)作為對照組.分析L1-CAM在IMPC的錶達及與臨床病理學特徵和預後的關繫.結果:L1-CAM錶達于腫瘤細胞膜及間質中的脈管內皮細胞,在IMPC組主要錶達于腫瘤細胞集糰內細胞間的相互連接麵.L1-CAM在IMPC中的錶達率(50.5%)顯著高于IDC-NOS組(18.9%),併與IMPC的組織學分級、脈管侵犯、淋巴結轉移、間質內脈管的L1-CAM錶達及腫瘤細胞的P53錶達呈正相關(P<0.05),與ER、PR錶達呈負相關(P<0.05).單因素分析結果顯示,IMPC患者中L1-CAM錶達暘性患者預後不良.多因素分析結果顯示IMPC中L1-CAM錶達是影響患者術後生存的獨立預後因素.結論:L1-CAM可能在IMPC集糰性生長、侵襲、轉移中髮揮重要作用,可作為IMPC預後預測的標誌物及靶嚮治療研究的新靶點.
목적:탐토 L1세포점부분자(L1 cell adhesion molecules,L1-CAM)재유선침윤성미유두상암(Invasive micropapillary carcinoma,IMPC)중적표체급기림상의의.방법:응용면역조직화학SP법,검측97례유선IMPC중L1-CAM표체,병이95례침윤성도관암비특수형(invasive ductal carcinoma,not otherwise specified,IDC-NOS)작위대조조.분석L1-CAM재IMPC적표체급여림상병이학특정화예후적관계.결과:L1-CAM표체우종류세포막급간질중적맥관내피세포,재IMPC조주요표체우종류세포집단내세포간적상호련접면.L1-CAM재IMPC중적표체솔(50.5%)현저고우IDC-NOS조(18.9%),병여IMPC적조직학분급、맥관침범、림파결전이、간질내맥관적L1-CAM표체급종류세포적P53표체정정상관(P<0.05),여ER、PR표체정부상관(P<0.05).단인소분석결과현시,IMPC환자중L1-CAM표체양성환자예후불량.다인소분석결과현시IMPC중L1-CAM표체시영향환자술후생존적독립예후인소.결론:L1-CAM가능재IMPC집단성생장、침습、전이중발휘중요작용,가작위IMPC예후예측적표지물급파향치료연구적신파점.
Objective: The study aims to investigate the expression of L1 cell adhesion molecules (L1-CAM) in invasion micropapillary carcinoma (IMPC) and to analyze its clinical significance. Methods: L1-CAM expression was analyzed in 97 IMPC cases and 95 invasive ductal carcinoma–not otherwise specified (IDC-NOS) cases via immunohistochemistry. The correlation of L1-CAM expression with clinicopathologic characteristics, which include the prognosis IMPC patients, was determined. Results: The rate of L1-CAM expression in IMPC (50.5%) is significantly higher than that of IDC-NOS (18.9%). L1-CAM expression is also associated with histological grade, vessel invasion, lymph node metastasis, L1-CAM vessels, and protein p53 expression (P<0.05), whereas it is negatively associated with ER and PR (P<0.05). L1-CAM was predominantly expressed in the cell-cell interface of the cell clusters of IMPC and in the stroma vascular en-dothelial cells. Univariate analysis results indicate that expression of L1 is a risk factor that can predict the survival of IMPC patients (P<0.05). Multivariate analyses results from a Cox's proportional hazards model show that a high expression of L1-CAM is an independent risk factor for the death of IMPC patients. Conclusion: This study suggests that L1-CAM expression may have an important function in collective cell growth and is significantly associated with tumor invasion and metastasis. L1-CAM can be considered as biomarkers of prognosis and as a new target for IMPC therapy.
