CAJ | 학술논문

结直肠癌是一种常见恶性肿瘤,近年来,微卫星不稳定性与结直肠癌的关系成为判断结直肠癌预后和预测化疗疗效方面研究的一个热点.微卫星不稳定性在判断结直肠癌的预后及指导结直肠癌的化疗方面有着重要作用.本文从微卫星不稳定性的概念,与结直肠癌预后相关性,与各期结直肠癌氟尿嘧啶类药物疗效间相关性等方面对微卫星不稳定性在结直肠癌中的相关进展进行综述,旨在为临床上应用微卫星不稳定性指导结直肠癌治疗方面提供相关依据.
결직장암시일충상견악성종류,근년래,미위성불은정성여결직장암적관계성위판단결직장암예후화예측화료료효방면연구적일개열점.미위성불은정성재판단결직장암적예후급지도결직장암적화료방면유착중요작용.본문종미위성불은정성적개념,여결직장암예후상관성,여각기결직장암불뇨밀정류약물료효간상관성등방면대미위성불은정성재결직장암중적상관진전진행종술,지재위림상상응용미위성불은정성지도결직장암치료방면제공상관의거.
Colorectal cancer (CRC) is one of the most common cancers worldwide. Microsatellite instability (MSI) is an important factor of prognosis that is essential in guiding CRC chemotherapy. Remarkable progress has been achieved in the management of CRC in recent years. Prognosis is better for patients with high-MSI (MSI-H) CRCs. The relationship between MSI status and response to che-motherapy is controversial. Many studies indicate that the good prognosis of MSI-H colorectal cancer is weakened by fluorouracil.