CAJ | 학술논문

目的:探讨经皮肝动脉栓塞化疗联合洛铂热灌注化疗在治疗肝细胞癌中的近期疗效.方法:对20例不能手术切除的肝细胞癌患者进行肝动脉热灌注化疗栓塞术,先采用洛铂联合盐酸表柔比星、丝裂霉素行热灌注化疗,然后行常规肝动脉栓塞化疗,间隔40~50天再次治疗,2次治疗后评价近期治疗效果及不良反应.结果:20例患者显效4例(20.0%),有效7例(35.0%),稳定7例(35.0%),进展2例(10.0%).总有效率为55.0%.AFP下降>50%者8例,其中2例恢复正常.结论:肝动脉热灌注洛铂为主的联合化疗方案+栓塞术治疗肝细胞癌安全有效,其远期疗效有待进一步观察.
목적:탐토경피간동맥전새화료연합락박열관주화료재치료간세포암중적근기료효.방법:대20례불능수술절제적간세포암환자진행간동맥열관주화료전새술,선채용락박연합염산표유비성、사렬매소행열관주화료,연후행상규간동맥전새화료,간격40~50천재차치료,2차치료후평개근기치료효과급불량반응.결과:20례환자현효4례(20.0%),유효7례(35.0%),은정7례(35.0%),진전2례(10.0%).총유효솔위55.0%.AFP하강>50%자8례,기중2례회복정상.결론:간동맥열관주락박위주적연합화료방안+전새술치료간세포암안전유효,기원기료효유대진일보관찰.
Objective:This study aims to explore the early-stage therapeutic effects of lobaplatin-based thermochemotherapy and embolization via hepatic artery intervention in the treatment of unresectable primary liver cancer. Methods:Thermochemotherapy and embolization were used to treat 20 unresectable primary liver cancer patients. Epirubicin, mitomycin, and lobaplatin were used for ther-mochemotherapy. The process was repeated once after 40 d to 50 d. After the two treatment periods, the early effects and side effects were observed. Results:Among the 20 cases, 4 (20.0%) received excellent efficacy, 7 (35.0%) received good effect, 7 (35.0%) demonstrated stabilization, and 2 showed advancement, with a total effective rate of 55.0%. The content of alpha fetoprotein dropped by over 50%in 8 cases, among which 2 returned to normal. Conclusion:The use of thermochemotherapy and embolization via hepatic artery intervention is an effective and safe treatment for primary liver cancer. However, the long-term effects of this treatment need further observation.