CAJ | 학술논문

Th17细胞在炎症、自身免疫、过敏和肿瘤等多种疾病中发挥着重要作用,但在肿瘤免疫中的作用却知之甚少.本文主要对Th17细胞在肿瘤微环境中分化相关的细胞因子,细胞内的信号传导通路和Th17细胞的迁移活动等内容进行回顾,并进一步阐述其在肿瘤形成过程中所发挥的双向作用,为寻求治疗肿瘤的靶点提供依据.
Th17세포재염증、자신면역、과민화종류등다충질병중발휘착중요작용,단재종류면역중적작용각지지심소.본문주요대Th17세포재종류미배경중분화상관적세포인자,세포내적신호전도통로화Th17세포적천이활동등내용진행회고,병진일보천술기재종류형성과정중소발휘적쌍향작용,위심구치료종류적파점제공의거.
Th17 cells have important functions in several diseases, including autoimmunity, inflammations, allergies, and tumors. However, the function of these cells in most tumor immunity cases remains unknown. The current study reviewed the current under-standing of molecular interactions, signal pathways, and cell migration that contribute to cell differentiation and functions of Th17 cells in a tumor microenvironment. This paper also summarized the conclusions regarding the functions of these cells in tumorigenesis to pro-vide basic guidelines for Th17-targeted therapy of tumors.