CAJ | 학술논문

纳米粒载药系统可以改变药物的体内分布特征,具有缓控释和靶向给药特性,增加药物的稳定性,提高药物的生物利用度.纳米粒的靶向选择性可以通过增强渗透滞留效应(EPR)、偶联特定的配体,或由于生理条件如pH值、温度等的改变实现.纳米粒可以由多种材料制备并且用于包合各种化学治疗药物以降低药物不良反应,其中,磁性纳米粒作为抗肿瘤药物载体不仅可以用来治疗还能用于成像诊断.本文综述了纳米粒被动靶向、主动靶向、物理化学靶向给药系统用于抗肿瘤药物载体的研究进展.
납미립재약계통가이개변약물적체내분포특정,구유완공석화파향급약특성,증가약물적은정성,제고약물적생물이용도.납미립적파향선택성가이통과증강삼투체류효응(EPR)、우련특정적배체,혹유우생리조건여pH치、온도등적개변실현.납미립가이유다충재료제비병차용우포합각충화학치료약물이강저약물불량반응,기중,자성납미립작위항종류약물재체불부가이용래치료환능용우성상진단.본문종술료납미립피동파향、주동파향、물이화학파향급약계통용우항종류약물재체적연구진전.
A nanoparticle drug carrier system that can change the characteristics of drug distribution in vivo has sustained and controlled release features as well as targeted drug delivery. The system can increase the stability of the drug and raise drug bioavailabil-ity. The selective targeting of nanoparticle (NPs) can be achieved through enhanced permeability and retention effect and a conjugated specific ligand or through the effects of physiological conditions, such as pH and temperature. Nanoparticles can be prepared using a wide range of materials and can be used to encapsulate chemotherapeutic agents to reduce toxicity with which the magnetic nanoparti-cles as the anticancer drug carrier can be used for imaging, therapy, and diagnosis. In our study, we reviewed recent progress on nanoparticles as a targeted drug delivery system, including positive-targeting, negative-targeting, and physicochemical-targeting used as anticancer drug carrier.