CAJ | 학술논문

NK/T细胞淋巴瘤(NK/T cell lymphoma,NKTCL)属高度侵袭性肿瘤,预后差,目前尚无明确有效的治疗方案.除了组织形态改变及EBV相关,该病也存在染色体异常、基因突变、信号通路及蛋白表达的异常.国内外学者由此出发,对其发病机制进行了持续的深入研究.本文就NKTCL发病机制的研究进展作一综述.
NK/T세포림파류(NK/T cell lymphoma,NKTCL)속고도침습성종류,예후차,목전상무명학유효적치료방안.제료조직형태개변급EBV상관,해병야존재염색체이상、기인돌변、신호통로급단백표체적이상.국내외학자유차출발,대기발병궤제진행료지속적심입연구.본문취NKTCL발병궤제적연구진전작일종술.
NK/T-cell lymphoma has a poor prognosis because of the invasiveness of this disease. No effective treatments exist for this condition. Aside from causing histologic and EBV-related changes, the disease also causes chromosome abnormality, gene mutation, and abnormality in the signal pathway and protein expression. Thus, many domestic and international scholars have conducted sustainable in-depth studies on the pathogenesis of the tumor. This paper summarizes the research progress on the pathogenesis of NK/T-cell lymphoma.