中国中西医结合急救杂志
中國中西醫結閤急救雜誌
중국중서의결합급구잡지
INTEGRATED TRADITIONAL CHINESE AND WESTERN MEDICINE IN PRACTICE OF CRITICAL CARE MEDICINE
2012年
6期
358-360
,共3页
沈继春%钟士江%李双英%李戈菲
瀋繼春%鐘士江%李雙英%李戈菲
침계춘%종사강%리쌍영%리과비
脑梗死%血小板参数%凝血功能%血脂
腦梗死%血小闆參數%凝血功能%血脂
뇌경사%혈소판삼수%응혈공능%혈지
Cerebral infarction%Platelet parameters%Coagulation function%Blood lipid
目的探讨急性脑梗死患者血小板各参数、凝血功能及血脂的变化.方法选择本院住院的急性脑梗死患者74例为急性脑梗死组,以同期本院65例健康查体者作为健康对照组.两组均空腹取静脉血,测定血小板各参数、凝血功能及血脂水平.结果与健康对照组比较,脑梗死组血小板计数(PLT )明显减少(×109/L :191.01±62.65比234.54±77.60),平均血小板体积〔MPV(fl):16.51±1.37比10.16±1.76〕及血小板分布宽度〔PDW:(22.74±3.71)%比(13.02±2.96)%〕明显增大(均 P<0.05),血小板比容(PCT :0.40±0.14比0.37±0.14)、大血小板比例(P-LCR:0.37±0.10比0.32±0.09)比较差异均无统计学意义(均P>0.05);活化部分凝血活酶时间〔APTT(s):29.13±4.66比36.32±3.84〕、凝血酶原时间〔PT(s):11.38±1.27比12.49±0.92〕则明显缩短(均 P<0.05);纤维蛋白原〔Fib(g/L):5.11±0.82比3.37±0.73〕及 D-二聚体(μg/L :790.23±471.69比377.29±140.41)均明显增高(均 P<0.05),凝血酶原活动度〔(92.28±15.33)%比(107.69±12.03)%〕、凝血酶时间〔TT(s):16.04±2.06比15.66±1.74〕、凝血酶原国际标准化比值(PT-INR,0.96±0.15 比1.02±0.15)比较差异均无统计学意义(均 P>0.05);总胆固醇〔TC(mmol/L):5.31±1.06比3.84±0.80〕、甘油三酯〔TG(mmol/L):3.20±1.39比2.29±0.77〕及低密度脂蛋白〔LDL(mmol/L):3.05±0.60比2.29±0.77〕均明显增高(均 P<0.05),高密度脂蛋白〔HDL(mmol/L):0.71±0.17 比0.75±0.20〕比较差异无统计学意义(P>0.05).结论血小板质和量的异常、凝血功能改变及脂代谢的紊乱是急性脑梗死的重要发病因素.
目的探討急性腦梗死患者血小闆各參數、凝血功能及血脂的變化.方法選擇本院住院的急性腦梗死患者74例為急性腦梗死組,以同期本院65例健康查體者作為健康對照組.兩組均空腹取靜脈血,測定血小闆各參數、凝血功能及血脂水平.結果與健康對照組比較,腦梗死組血小闆計數(PLT )明顯減少(×109/L :191.01±62.65比234.54±77.60),平均血小闆體積〔MPV(fl):16.51±1.37比10.16±1.76〕及血小闆分佈寬度〔PDW:(22.74±3.71)%比(13.02±2.96)%〕明顯增大(均 P<0.05),血小闆比容(PCT :0.40±0.14比0.37±0.14)、大血小闆比例(P-LCR:0.37±0.10比0.32±0.09)比較差異均無統計學意義(均P>0.05);活化部分凝血活酶時間〔APTT(s):29.13±4.66比36.32±3.84〕、凝血酶原時間〔PT(s):11.38±1.27比12.49±0.92〕則明顯縮短(均 P<0.05);纖維蛋白原〔Fib(g/L):5.11±0.82比3.37±0.73〕及 D-二聚體(μg/L :790.23±471.69比377.29±140.41)均明顯增高(均 P<0.05),凝血酶原活動度〔(92.28±15.33)%比(107.69±12.03)%〕、凝血酶時間〔TT(s):16.04±2.06比15.66±1.74〕、凝血酶原國際標準化比值(PT-INR,0.96±0.15 比1.02±0.15)比較差異均無統計學意義(均 P>0.05);總膽固醇〔TC(mmol/L):5.31±1.06比3.84±0.80〕、甘油三酯〔TG(mmol/L):3.20±1.39比2.29±0.77〕及低密度脂蛋白〔LDL(mmol/L):3.05±0.60比2.29±0.77〕均明顯增高(均 P<0.05),高密度脂蛋白〔HDL(mmol/L):0.71±0.17 比0.75±0.20〕比較差異無統計學意義(P>0.05).結論血小闆質和量的異常、凝血功能改變及脂代謝的紊亂是急性腦梗死的重要髮病因素.
목적탐토급성뇌경사환자혈소판각삼수、응혈공능급혈지적변화.방법선택본원주원적급성뇌경사환자74례위급성뇌경사조,이동기본원65례건강사체자작위건강대조조.량조균공복취정맥혈,측정혈소판각삼수、응혈공능급혈지수평.결과여건강대조조비교,뇌경사조혈소판계수(PLT )명현감소(×109/L :191.01±62.65비234.54±77.60),평균혈소판체적〔MPV(fl):16.51±1.37비10.16±1.76〕급혈소판분포관도〔PDW:(22.74±3.71)%비(13.02±2.96)%〕명현증대(균 P<0.05),혈소판비용(PCT :0.40±0.14비0.37±0.14)、대혈소판비례(P-LCR:0.37±0.10비0.32±0.09)비교차이균무통계학의의(균P>0.05);활화부분응혈활매시간〔APTT(s):29.13±4.66비36.32±3.84〕、응혈매원시간〔PT(s):11.38±1.27비12.49±0.92〕칙명현축단(균 P<0.05);섬유단백원〔Fib(g/L):5.11±0.82비3.37±0.73〕급 D-이취체(μg/L :790.23±471.69비377.29±140.41)균명현증고(균 P<0.05),응혈매원활동도〔(92.28±15.33)%비(107.69±12.03)%〕、응혈매시간〔TT(s):16.04±2.06비15.66±1.74〕、응혈매원국제표준화비치(PT-INR,0.96±0.15 비1.02±0.15)비교차이균무통계학의의(균 P>0.05);총담고순〔TC(mmol/L):5.31±1.06비3.84±0.80〕、감유삼지〔TG(mmol/L):3.20±1.39비2.29±0.77〕급저밀도지단백〔LDL(mmol/L):3.05±0.60비2.29±0.77〕균명현증고(균 P<0.05),고밀도지단백〔HDL(mmol/L):0.71±0.17 비0.75±0.20〕비교차이무통계학의의(P>0.05).결론혈소판질화량적이상、응혈공능개변급지대사적문란시급성뇌경사적중요발병인소.
Objective To explore the changes of platelet parameters,coagulation function and blood lipids of patients with acute cerebral infarction. Methods Seventy-four patients with acute cerebral infarction were enrolled as the observation group,and 65 healthy people during the same period were chosen as the controls. Venous blood was collected at fast,and the platelet parameters,coagulation function and blood lipids were determined in both groups. Results The platelet count(PLT)of the acute cerebral infarction group was obviously decreased compared with that of the healthy control group(×109/L :191.01±62.65 vs. 234.54±77.60),while the mean platelet volume〔MPV(fl):16.51±1.37 vs. 10.16±1.76〕and platelet distribution width〔PDW:(22.74±3.71)% vs.(13.02±2.96)%〕were significantly higher than those in the healthy control group(all P<0.05). Plateletocrit(PCT :0.40±0.14 vs. 0.37±0.14)and platelet large cell ratio(P-LCR:0.37±0.10 vs. 0.32±0.09)had no statistically significant differences compared with those of the healthy control group(both P>0.05). Activated partial thromboplastin time〔APTT(s):29.13±4.66 vs. 36.32±3.84〕and plasma prothrombin time〔PT(s):11.38±1.27 vs. 12.49±0.92〕were obviously shorter in cerebral infarction group than those in healthy control group(both P<0.05);fibrinogen〔Fib(g/L):5.11±0.82 vs. 3.37±0.73〕and D-Dimer(μg/L :790.23±471.69 vs. 377.29±140.41)were significantly higher than those in healthy control group(both P<0.05). Prothrombin activity〔(92.28±15.33)% vs.(107.69±12.03)%〕, thrombin time〔TT(s):16.04±2.06 vs.15.66±1.74〕 and prothrombin time-international normalized ratio (PT-INR :0.96±0.15 vs. 1.02±0.15)had no statistical differences compared with those of the control group(all P>0.05);Total cholesterol〔TC(mmol/L):5.31±1.06 vs. 3.84±0.80〕,triglyceride〔TG(mmol/L):3.20±1.39 vs. 2.29±0.77〕and low-density lipoprotein〔LDL(mmol/L):3.05±0.60 vs. 2.29±0.77〕were obviously higher in cerebral infarction group than those in healthy control group(all P<0.05). High-density lipoprotein〔HDL (mmol/L):0.71±0.17 vs. 0.75±0.20〕had no statistical difference compared with that of the healthy control group(P>0.05). Conclusion The abnormality of the quality and number with platelet,the change of coagulation function and dyslipidemia were the important factors in the pathogenesis of acute cerebral infarction.
