CAJ | 학술논문

目的:测定小儿臂丛神经阻滞丙泊酚靶控输注的半数有效血浆靶控浓度.方法:择期臂丛麻醉下行前臂或手外科手术患儿,术前30 min口服咪达唑仑镇静,序贯法靶控输注丙泊酚,初始血浆靶浓度设为5.0μg/mL,待患儿睫毛反射消失和对言语指令无反应时,行腋路臂丛神经阻滞.结果:丙泊酚TCI抑制小儿臂丛神经阻滞时患儿体动反应的半数有效血浆靶控浓度为3.9μg/mL,95%可信区间为3.6~4.2μg/mL.结论:口服咪达唑仑镇静下,丙泊酚抑制臂丛神经阻滞时患儿体动反应的半数有效血浆靶控浓度为3.9μg/mL.
목적:측정소인비총신경조체병박분파공수주적반수유효혈장파공농도.방법:택기비총마취하행전비혹수외과수술환인,술전30 min구복미체서륜진정,서관법파공수주병박분,초시혈장파농도설위5.0μg/mL,대환인첩모반사소실화대언어지령무반응시,행액로비총신경조체.결과:병박분TCI억제소인비총신경조체시환인체동반응적반수유효혈장파공농도위3.9μg/mL,95%가신구간위3.6~4.2μg/mL.결론:구복미체서륜진정하,병박분억제비총신경조체시환인체동반응적반수유효혈장파공농도위3.9μg/mL.
Objective To determine the effective target plasma concentration of propofol required to pre?vent body dynamic response under brachial plexus block in 50% of children (Cp50). Methods ASA I or 11 children aged 5~8yrs undergoing elective forearm or hand surgery were enrolled in this study,midazolam was ad?ministered 30min before the propofol given by TCI at a target plasma concentration of 5.0 μg/mL, the cp50 was determined by up-and-down sequential experiment.When the patients lost consciousness and had no reaction to verbal instructions,axillary road block brachial plexus was done,the effect of TCI of propofol was based on the movement of the body in response to brachial plexus block.If effective the target plasma propofol concentration was set at a lower concentration in the next patient and vice versa.Each time the target plasma propofol concen?tration increased/decreased by 1.2 folds.The up-and-down sequences were analyzed by using the Dixon and Massey method to determine the Cp50. Results The Cp50 of propofol by TCI for brachial plexus block was 3.9μg/mL[95%confidence interval(CI)3.6-4.2μg/mL]. Conclusion The Cp50 of propofol by TCI for brachial plex?us block with midazolam orally in children is 3.9μg/mL.