CAJ | 학술논문

目的:探讨手术治疗垂体泌乳素大腺瘤的临床疗效,以及对机体内分泌的影响.方法:收集符合标准的患者45例,观察手术前后血清泌乳素(PRL)、雌二醇(E2)、促卵泡素(FSH)、黄体生成素(LH)、孕酮(P)和睾酮(T)等水平变化以及对应各种激素刺激后FSH、LH和睾酮(T)的变化,并对患者临床疗效进行评定.结果:患者术后3个月、6个月和1年进行临床疗效评价,有效率分别为37.78%、60.00%和75.56%;患者术后1年血清PRL水平与术前比较,显著下降.术前促卵泡素(FSH)、黄体生成素(LH)的水平分别为(10.52±8.17)和(6.28±4.74)mIU/mL,GnRH激素刺激后,LH水的峰值达到(12.34±1.78)(P<0.05),而FSH的最高峰值为(11.28±2.30)(P>0.05);术后LH和FSH与手术之前相比显著升高.睾酮(T)术前与术后的水平有统计学意义,但是hCG反应的峰值没有显著区别.结论:泌乳素大腺瘤通过下丘脑-垂体-性腺轴影响一系列促性腺激素的释放进而影响生殖器官的功能,手术治疗垂体泌乳素大腺瘤临床疗效确切,可以显著改善患者内分泌激素水平.
목적:탐토수술치료수체비유소대선류적림상료효,이급대궤체내분비적영향.방법:수집부합표준적환자45례,관찰수술전후혈청비유소(PRL)、자이순(E2)、촉란포소(FSH)、황체생성소(LH)、잉동(P)화고동(T)등수평변화이급대응각충격소자격후FSH、LH화고동(T)적변화,병대환자림상료효진행평정.결과:환자술후3개월、6개월화1년진행림상료효평개,유효솔분별위37.78%、60.00%화75.56%;환자술후1년혈청PRL수평여술전비교,현저하강.술전촉란포소(FSH)、황체생성소(LH)적수평분별위(10.52±8.17)화(6.28±4.74)mIU/mL,GnRH격소자격후,LH수적봉치체도(12.34±1.78)(P<0.05),이FSH적최고봉치위(11.28±2.30)(P>0.05);술후LH화FSH여수술지전상비현저승고.고동(T)술전여술후적수평유통계학의의,단시hCG반응적봉치몰유현저구별.결론:비유소대선류통과하구뇌-수체-성선축영향일계렬촉성선격소적석방진이영향생식기관적공능,수술치료수체비유소대선류림상료효학절,가이현저개선환자내분비격소수평.
Objective: To Investigate the clinical efficacy on treatment of pituitary prolactin macroadeno?mas, and endocrine changes. Methods Collection of standards-compliant 45 patients, observing before and af?ter surgery the serum prolactin (PRL), estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), progesterone (P) and testosterone (T) levels, gonadotropin and testosterone response to their respective stim?uli, and clinical efficacy were assessed. Results The patients were at postoperatively 3m, 6m and 1 yr evaluat?ed the clinical efficiency of 37.78%, 60.00% and 75.56%, respectively. Serum prolactin levels decreased after 1 year of surgery. Pretreatmently, the mean lutenizing and follicle stimulating hormones(LH and FSH)levels were (6.28±4.74)and(10.52±8.17)mIU/mL respectively. However, LH responded to GnRH peaked to(12.34±1.78) (P<0.05), while FSH to(11.28±2.30). After surgery, there was an increase from basal level, but stimulated LH and FSH levels were not statistically improved after surgery. Basal testosterone levels significantly improved after surgery, but peak T response to hCG was similar before and after surgery. Conclusion The clinical effi?cacy of surgical treatment of pituitary prolactin adenoma can significantly improve patient’s level of hormone.