中国卒中杂志
中國卒中雜誌
중국졸중잡지
CHINESE JOURNAL OF STROKE
2013年
3期
183-189
,共7页
王海鹏%刘洁%王春雨%李冬华%蒋初明
王海鵬%劉潔%王春雨%李鼕華%蔣初明
왕해붕%류길%왕춘우%리동화%장초명
卒中%卒中后抑郁%同型半胱氨酸
卒中%卒中後抑鬱%同型半胱氨痠
졸중%졸중후억욱%동형반광안산
Stroke%Post-stroke depression%Homocysteine
目的研究卒中亚急性期发生的卒中后抑郁(post-stroke depression,PSD)与卒中急性期血浆同型半胱氨酸(homocysteine,Hcy)水平的相关性.方法连续收集2010年4月~2011年7月北京航天总医院神经内科住院的198例缺血性卒中患者,根据《中国精神疾病分类方案与诊断标准》第3版(Chinese Classification and Diagnostic Criteria of Mental Disorders-3,CCMD-3)进行PSD的诊断,根据诊断结果分为PSD组102例和卒中后无抑郁组(对照组)96例.由固定的、经过培训的心理咨询师对PSD患者进行汉密尔顿抑郁量表17项(Hamilton Rating Scale for Depression-17,HRSD-17)评定,根据评定结果分为轻度、中度、重度抑郁组.采用微量荧光偏振免疫分析法于入院次日对所有患者进行血浆Hcy水平测定,比较两组患者血浆Hcy水平,并与PSD进行相关分析.结果 PSD组102例患者有高同型半胱氨酸血症(hyperhomocysteinemia,HHcy)68例(66.7%),对照组有12例(12.5%),PSD组HHcy阳性检出率较对照组差异具有显著性(χ2=17.29,P<0.001).经非条件Logistic回归分析PSD的危险因素,显示血浆Hcy水平与PSD有相关性[优势比(odds ratio,OR)=1.946, P﹤0.001,95%可信区间(confidence interval,CI)1.10~1.22].结论卒中急性期血浆Hcy水平与卒中亚急性期抑郁有相关性.
目的研究卒中亞急性期髮生的卒中後抑鬱(post-stroke depression,PSD)與卒中急性期血漿同型半胱氨痠(homocysteine,Hcy)水平的相關性.方法連續收集2010年4月~2011年7月北京航天總醫院神經內科住院的198例缺血性卒中患者,根據《中國精神疾病分類方案與診斷標準》第3版(Chinese Classification and Diagnostic Criteria of Mental Disorders-3,CCMD-3)進行PSD的診斷,根據診斷結果分為PSD組102例和卒中後無抑鬱組(對照組)96例.由固定的、經過培訓的心理咨詢師對PSD患者進行漢密爾頓抑鬱量錶17項(Hamilton Rating Scale for Depression-17,HRSD-17)評定,根據評定結果分為輕度、中度、重度抑鬱組.採用微量熒光偏振免疫分析法于入院次日對所有患者進行血漿Hcy水平測定,比較兩組患者血漿Hcy水平,併與PSD進行相關分析.結果 PSD組102例患者有高同型半胱氨痠血癥(hyperhomocysteinemia,HHcy)68例(66.7%),對照組有12例(12.5%),PSD組HHcy暘性檢齣率較對照組差異具有顯著性(χ2=17.29,P<0.001).經非條件Logistic迴歸分析PSD的危險因素,顯示血漿Hcy水平與PSD有相關性[優勢比(odds ratio,OR)=1.946, P﹤0.001,95%可信區間(confidence interval,CI)1.10~1.22].結論卒中急性期血漿Hcy水平與卒中亞急性期抑鬱有相關性.
목적연구졸중아급성기발생적졸중후억욱(post-stroke depression,PSD)여졸중급성기혈장동형반광안산(homocysteine,Hcy)수평적상관성.방법련속수집2010년4월~2011년7월북경항천총의원신경내과주원적198례결혈성졸중환자,근거《중국정신질병분류방안여진단표준》제3판(Chinese Classification and Diagnostic Criteria of Mental Disorders-3,CCMD-3)진행PSD적진단,근거진단결과분위PSD조102례화졸중후무억욱조(대조조)96례.유고정적、경과배훈적심리자순사대PSD환자진행한밀이돈억욱량표17항(Hamilton Rating Scale for Depression-17,HRSD-17)평정,근거평정결과분위경도、중도、중도억욱조.채용미량형광편진면역분석법우입원차일대소유환자진행혈장Hcy수평측정,비교량조환자혈장Hcy수평,병여PSD진행상관분석.결과 PSD조102례환자유고동형반광안산혈증(hyperhomocysteinemia,HHcy)68례(66.7%),대조조유12례(12.5%),PSD조HHcy양성검출솔교대조조차이구유현저성(χ2=17.29,P<0.001).경비조건Logistic회귀분석PSD적위험인소,현시혈장Hcy수평여PSD유상관성[우세비(odds ratio,OR)=1.946, P﹤0.001,95%가신구간(confidence interval,CI)1.10~1.22].결론졸중급성기혈장Hcy수평여졸중아급성기억욱유상관성.
Objective To investigate the relationship between post-stroke depression(PSD) occurring in subacute phase of stroke and plasma level of homocysteine(Hcy) in acute stroke. Methods One hundred and ninety-eight ischemic stroke patients who were hospitalized at Department of Neurology of Beijing Aerospace General Hospital from April 2010 to July 2011 were consecutively recruited into our study. They were diagnosed PSD as defined in Chinese Classification and Diagnostic Criteria of Mental Disorders-3(CCMD-3). One hundred and two patients were diagnosed with PSD(PSD group) and 96 patients were not(control group). Those PSD patients were evaluated by the same trained psychological consultant with Hamilton Rating Scale for Depression-17(HRSD-17), and they were subdivided into three groups:mild, moderate and severe. All patients of interest were examined the level of plasma Hcy by fluorescence polarization immunoassay on the second day of hospitalization. Comparison of the levels of plasma Hcy between both groups was made and their relationship with PSD was analyzed. Results In the PSD group, 68 patients had hyperhomocysteinemia(HHcy)(66.7%), and the control group had 12 cases(12.5%). There was statistically significant difference in positive rate of HHcy between both groups. The unconditional Logistic regression analysis was adopted to evaluate the risk factors of PSD, and the results show that the plasma Hcy level is associated with PSD(odds ratio[OR]=1.946, P<0.001, 95%confidence interval[CI] 1.10-1.22).Conclusion The plasma level of Hcy in acute stroke is relevant to PSD in subacute phase of stroke.
