CAJ | 학술논문

目的运用Meta分析的方法分析亚甲基四氢叶酸还原酶基因C677T多态性与突发性聋发病相关性.方法计算机检索PUBMED、EMBASE、Cochrane图书馆(英文)和中国生物医学文献数据库(CBM)(中文),查找亚甲基四氢叶酸还原酶基因C677T多态性与突发性聋发病相关的临床研究,对纳入的文献进行严格方法学质量评价.应用RevMan4.2软件进行统计分析.结果共有7篇文献纳入研究,累计病例组388例,对照组2921例.方法学质量评价结果显示,4个研究为A级,3个研究为B级,总体研究质量较高.Meta分析结果提示亚甲基四氢叶酸还原酶基因C677T多态性在基因型水平[OR=1.79>1,95%CI=(1.06,3.02),P=0.03]和等位基因水平[OR=1.53>1,95%CI=(1.08,2.17),P=0.02]均可能增加突发性聋的发病风险.结论本研究提示亚甲基四氢叶酸还原酶基因C677T多态性可能增加突发性聋发病风险,本系统评价纳入的研究相对较少,上述结论尚需开展多中心大样本量的高质量研究进一步证实.
목적운용Meta분석적방법분석아갑기사경협산환원매기인C677T다태성여돌발성롱발병상관성.방법계산궤검색PUBMED、EMBASE、Cochrane도서관(영문)화중국생물의학문헌수거고(CBM)(중문),사조아갑기사경협산환원매기인C677T다태성여돌발성롱발병상관적림상연구,대납입적문헌진행엄격방법학질량평개.응용RevMan4.2연건진행통계분석.결과공유7편문헌납입연구,루계병례조388례,대조조2921례.방법학질량평개결과현시,4개연구위A급,3개연구위B급,총체연구질량교고.Meta분석결과제시아갑기사경협산환원매기인C677T다태성재기인형수평[OR=1.79>1,95%CI=(1.06,3.02),P=0.03]화등위기인수평[OR=1.53>1,95%CI=(1.08,2.17),P=0.02]균가능증가돌발성롱적발병풍험.결론본연구제시아갑기사경협산환원매기인C677T다태성가능증가돌발성롱발병풍험,본계통평개납입적연구상대교소,상술결론상수개전다중심대양본량적고질량연구진일보증실.
Objective To investigate the association between MTHFR C677T polymorphism and the risk for sudden sen?sorineural hearing loss (SSNHL) using meta-analysis methodology. Methods Databases including PUBMED, EMBASE, Co?chrane Library and CBM were searched to collect case control studies on the correlation between MTHFR C677T polymor?phism and sudden sensorineural hearing loss. Only high quality studies were included. All analyses were conducted with the Review Manager Version 4.2 software. Results A total of 7 studies were included, involving 388 patients and 2921 controls. The quality assessment indicated Level A quality in 4 studies and Level B quality in 3 studies. Meta-analysis showed that the MTHFR C677T polymorphism frequencies at genotypes and alleles levels were associated with increased risk for SSNHL [OR=1.79 and 1.53, 95%CI=(1.06 ,3.02) and (1.08,2.17), and P=0.03 and 0.02,respectively]. Conclusions The Meta-analysis sug?gests that the MTHFR C677T polymorphism may be a genetic risk factor for sudden sensorineural hearing loss. However, this conclusion remains to be confirmed by high-quality, large-scale and multi-center studies.