CAJ | 학술논문

目的总结2A型多发性内分泌腺瘤病(MEN)的超声声像图特征.方法回顾性分析解放军第一一七医院经基因检测均为Ret第11号外显子C634Y突变的12个家族中的57例2A型MEN患者甲状腺及肾上腺超声表现.所有患者均经病理证实.结果57例2A型MEN患者单侧或双侧甲状腺均可见单发或多发低回声或混合性回声结节,18例合并肾上腺单侧或双侧单发或多发低回声或混合性占位.经手术病理或超声引导穿刺活检证实单侧或双侧甲状腺髓样癌51例(89.5%),甲状腺髓样癌并甲状腺乳头状癌4例(7.0%),甲状腺C细胞增生2例(3.5%),淋巴结转移4例(7.1%),单侧或双侧肾上腺嗜铬细胞瘤18例(31.6%).结论2A型多发性内分泌腺瘤病超声表现具有特异性,超声检查可早期提示此病.
목적총결2A형다발성내분비선류병(MEN)적초성성상도특정.방법회고성분석해방군제일일칠의원경기인검측균위Ret제11호외현자C634Y돌변적12개가족중적57례2A형MEN환자갑상선급신상선초성표현.소유환자균경병리증실.결과57례2A형MEN환자단측혹쌍측갑상선균가견단발혹다발저회성혹혼합성회성결절,18례합병신상선단측혹쌍측단발혹다발저회성혹혼합성점위.경수술병리혹초성인도천자활검증실단측혹쌍측갑상선수양암51례(89.5%),갑상선수양암병갑상선유두상암4례(7.0%),갑상선C세포증생2례(3.5%),림파결전이4례(7.1%),단측혹쌍측신상선기락세포류18례(31.6%).결론2A형다발성내분비선류병초성표현구유특이성,초성검사가조기제시차병.
Objective To explore the sonographic features of multiple endocrine neoplasia 2A (MEN2A).Methods The sonographic findings of MEN2A in 57 cases the 117th Hospital of People′s Liberation Army with Ret-C634Y mutation were summarized retrospectively .These patients involved 12 families.All patients were proved by pathology .Results Thyroid nodules were found in all 57 cases,which presented with various quantity ( single or multiple ), echogenecity ( hypoechoic or mixed ) and location (unilateral or bilateral).Eighteen patients had single or multiple adrenal nodules with unilateral or bilateral distribution.On pathology,the diagnoses were:unilateral or bilateral medullary thyroid carcinoma in 51 cases (89.5%),medullary carcinoma of thyroid and papillary carcinoma of thyroid in 4 cases(7.0%),thyroid C cell hyperplasia in 2 cases (3.5%), lymph node metastasis in 4 cases (7.1%), unilateral or bilateral pheochromocytomas in 18 cases(31.6%).Conclusions MEN2A has some specific features on sonography . Ultrasound may be useful in the early diagnosis of this disease .