CAJ | 학술논문

目的通过检测冠心病(CHD)患者体内超敏C-反应蛋白(hs-CRP)、低密度脂蛋白(LDL-C)和高密度脂蛋白(HDL-C)水平,研究HS-CRP与LDL-C/HDL-C冠心病及冠心病病变程度中的临床意义.方法根据冠状动脉(简称冠脉)造影结果的Gensini评分,将患者分为四组:(1)冠脉造影正常组(64例):Gensini评分0分.(2)冠脉轻度病变组(61例):Gensini评分<10分.(3)中度病变组(32例):Gensini评分10-30分.(4)重度病变组(61例):Gensini评分>30分.比较四组hS-CRP及LDL-C/HDL-C升高与冠心病的相关程度.结果冠心病组患者的hs-CRP浓度和LDL-C/HDL-C均显著高于冠脉正常组(P<0.05).另外,hS-CRP浓度在冠脉中度病变组显著高于冠脉轻度病变组(P<0.05);冠脉重度病变组显著高于冠脉中度病变组(P<0.05).结论血hS-CRP和LDL-C/HDL-C均与冠脉病变密切相关,而且hS-CRP与病变的严重程度(据Gensini评分)呈正相关,可作为对冠脉病变程度的估测指标.虽血液中LDL-C/HDL-C与冠状动脉病变密切相关,但很难完全据此指标来预测其病变程度.
목적통과검측관심병(CHD)환자체내초민C-반응단백(hs-CRP)、저밀도지단백(LDL-C)화고밀도지단백(HDL-C)수평,연구HS-CRP여LDL-C/HDL-C관심병급관심병병변정도중적림상의의.방법근거관상동맥(간칭관맥)조영결과적Gensini평분,장환자분위사조:(1)관맥조영정상조(64례):Gensini평분0분.(2)관맥경도병변조(61례):Gensini평분<10분.(3)중도병변조(32례):Gensini평분10-30분.(4)중도병변조(61례):Gensini평분>30분.비교사조hS-CRP급LDL-C/HDL-C승고여관심병적상관정도.결과관심병조환자적hs-CRP농도화LDL-C/HDL-C균현저고우관맥정상조(P<0.05).령외,hS-CRP농도재관맥중도병변조현저고우관맥경도병변조(P<0.05);관맥중도병변조현저고우관맥중도병변조(P<0.05).결론혈hS-CRP화LDL-C/HDL-C균여관맥병변밀절상관,이차hS-CRP여병변적엄중정도(거Gensini평분)정정상관,가작위대관맥병변정도적고측지표.수혈액중LDL-C/HDL-C여관상동맥병변밀절상관,단흔난완전거차지표래예측기병변정도.
Objective To study the clinical significance of combined detection in coronary artery disease through testing hs-CRP,LDL-C/HDL-C of coronary heart disease(CHD)patients.Methods According to the Gensini score of CAG , the patients were divided into four groups,the first group:the mild stenosis of coronary artery(<10),the second group:the moderate stenosis of coronary artery(10-30),the third group:the obvious stenosis of coronary artery(>30),the forth group:the normal group(=0),and Measured their hs-CRP,LDL-C/HDL-C.Results The serum hs-CRP levels and LDL-C/HDL-C in patients with coronary heart disease were significantly increased than those in normal group(P<0.05).In addition,hS - CRP levels in coronary artery coronary moderate lesion group is significantly higher than mild coronary artery lesion group(P<0.05);Severe lesion group is significantly higher than coronary moderate lesion group(P<0.05).Conclusion hS-CRP and LDL-C/HDL-C and coronary artery lesions are closely related,and hS-CRP is associated with the severity of the disease(according to the Gensini score),which can be used as to coronary artery lesion degree of estimation index.Although the serum levels of LDL-C/HDL-C are closely related to coronary artery lesions, it is hard to predict the degree of pathological changes fully accordingly to the such index.