CAJ | 학술논문

目的通过量化分析颈动脉斑块成分,探讨斑块中脂质比例与LDL-C等心血管危险因素的相关性.方法采用超声影像量化分析171例疑似颈动脉狭窄及颈动脉硬化患者颈动脉斑块中脂质比例,并与年龄、性别、SBP、DBP、TC、TG、HDL-C、IL-6、MMP-9等心血管危险因素进行相关性分析.结果与无斑块者比较,II型斑块者饮酒、肥胖比例增高(均P<0.05),I型斑块、II型斑块、III型斑块患者SBP、TC、TG、LDL-C、CRP、IL-6、MMP-9水平均升高(P<0.05或0.01),血清HDL-C降低(P<0.05).颈动脉斑块中脂质比例与IL-6、MMP-9、SBP、TC、TG、LDL-C、CRP呈正相关(均P<0.05),与HDL-C呈负相关(P<0.05),且与饮酒、肥胖等心血管危险因素有关(r=0.273、0.261,P<0.05).结论颈动脉斑块中脂质比例与LDL-C等心血管危险因素有密切关系,是影响动脉斑块稳定性的重要病理因素,可作为预测临床心血管疾病的危险因子.
목적통과양화분석경동맥반괴성분,탐토반괴중지질비례여LDL-C등심혈관위험인소적상관성.방법채용초성영상양화분석171례의사경동맥협착급경동맥경화환자경동맥반괴중지질비례,병여년령、성별、SBP、DBP、TC、TG、HDL-C、IL-6、MMP-9등심혈관위험인소진행상관성분석.결과여무반괴자비교,II형반괴자음주、비반비례증고(균P<0.05),I형반괴、II형반괴、III형반괴환자SBP、TC、TG、LDL-C、CRP、IL-6、MMP-9수평균승고(P<0.05혹0.01),혈청HDL-C강저(P<0.05).경동맥반괴중지질비례여IL-6、MMP-9、SBP、TC、TG、LDL-C、CRP정정상관(균P<0.05),여HDL-C정부상관(P<0.05),차여음주、비반등심혈관위험인소유관(r=0.273、0.261,P<0.05).결론경동맥반괴중지질비례여LDL-C등심혈관위험인소유밀절관계,시영향동맥반괴은정성적중요병리인소,가작위예측림상심혈관질병적위험인자.
Objective To investigate the relationship between the proportion of lipid in carotid arterial plaque and various cardiovascular risk factors. Methods The proportion of lipid in carotid arterial plaque was measured by ultrasound densitometry analysis in 171 patients with suspected carotid atherosclerotic plaques. The correlation of components of plaque with various cardiovascular risk factors, including age, gender, pulse pressure, TC, TG, HDL-C, IL-6, MMP-9 was analyzed. Results The rates of alcohol drinking and obesity in plaque II group were higher than those in non-plaque group (P<0.05). Compared with the non-plaque group, the levels of SBP,TC,TG,LDC-C,CRP,IL-6,MMP-9 of plaque I, plaque II and plaque III groups were higher, the levels of HDL-C were lower (P<0.05 or 0.01). The proportion of lipid in carotid arterial plaque showed positive corre-lation with the levels of IL-6, MMP-9, BP, TC, TG, LDL-C, CRP (P<0.05), and negative correlation with the levels of HDL-C (P<0.05). Alcohol drinking and obesity were associated with cardiovascular risk (r=0.273、0.261, P<0.05). Conclusion The propor-tion of lipid in carotid arterial plaque is closely related to various cardiovascular risk factors, it is also associated with the stability of plaque.