CAJ | 학술논문

目的探讨血清心肌肌钙蛋白T(cTnT)和CK在老年重症肺炎患者中的临床意义及对预后的影响.方法观察181例老年重症肺炎患者入院后3d内最高cTnT、CK测值和APACHE II评分,并对3者进行相关性分析.将患者分为cTnT正常组和升高组,比较两组的APACHE II评分和病死率.依据预后分为生存组和死亡组,比较两组cTnT、CK测值的变化.结果 cTnT正常组APACHE II评分和死亡例数与升高组差异有统计学意义(P<0.05).生存组cTnT、CK测值和APACHE II评分与死亡组差异均有统计学意义(均P<0.01),cTnT、CK与APACHE II评分3者之间呈正相关(均P<0.01).生存组cTnT、CK和APACHE II评分为(0.056±0.023)ng/ml、(135.67±20.71)μg/L和(17.4±2.8)分;死亡组cTnT、CK和APACHE II评分为(0.92±0.035)ng/ml、(210.22±32.6)μg/L和(24.8±5.6)分.结论老年重症患者cTnT、CK升高较常见,cTnT、CK监测对判断老年重症肺炎的预后具有一定临床意义.
목적탐토혈청심기기개단백T(cTnT)화CK재노년중증폐염환자중적림상의의급대예후적영향.방법관찰181례노년중증폐염환자입원후3d내최고cTnT、CK측치화APACHE II평분,병대3자진행상관성분석.장환자분위cTnT정상조화승고조,비교량조적APACHE II평분화병사솔.의거예후분위생존조화사망조,비교량조cTnT、CK측치적변화.결과 cTnT정상조APACHE II평분화사망례수여승고조차이유통계학의의(P<0.05).생존조cTnT、CK측치화APACHE II평분여사망조차이균유통계학의의(균P<0.01),cTnT、CK여APACHE II평분3자지간정정상관(균P<0.01).생존조cTnT、CK화APACHE II평분위(0.056±0.023)ng/ml、(135.67±20.71)μg/L화(17.4±2.8)분;사망조cTnT、CK화APACHE II평분위(0.92±0.035)ng/ml、(210.22±32.6)μg/L화(24.8±5.6)분.결론노년중증환자cTnT、CK승고교상견,cTnT、CK감측대판단노년중증폐염적예후구유일정림상의의.
Objective To investigate the clinical significance of serum cardiac tropinin T (cTnT) and creatine kinase (CK) levels in elderly patients with sever pneumonia. Methods Serum cTnT and CK levels were measured and APACHE II scores were assessed in 181 elderly patients with severe pneumonia within 3d after adimission. Patients were stratified into elevated and normal cTnT groups accordig to serum cTnT levels. Results There were significant differences in APACHE II score and mortality be-tween the elevated and normal cTnT groups (P<0.05). Serum cTnT levels were positively correlated with CK levels and APACHE II scores (P<0.01). Serum cTnT, CK and APACHE II score in the survival group were 0.056±0.023 ng/ml, 135.67±20.71μg/L and 17.4 ±2.8 respectively, while those in the fatal group were 0.92 ±0.035ng/ml, 210.22 ±32.6μg/L and 24.8 ±5.6 respectively. Conclusion Serum cTnT and CK levels can be used for evaluation of the prognosis in elderly patients with severe pneumonia.